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   Articles with "primaquine" as a keyword



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Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation.

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recommendations! Published in 2018 at "Drug metabolism and pharmacokinetics"

DOI: 10.1016/j.dmpk.2018.08.004

Abstract: Cytochrome P450 2D6 (CYP2D6) is responsible for the metabolic activation of primaquine, an antimalarial drug. CYP2D6 is genetically polymorphic, and these polymorphisms are associated with interindividual variations observed in the therapeutic efficacy of primaquine. To… read more here.

Keywords: cyp2d6 allelic; cyp2d6; allelic variants; primaquine hydroxylation ... See more keywords
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An unexpected Griess reaction on the important anti-malarial drug primaquine and its application for drug determination.

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recommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"

DOI: 10.1016/j.jpba.2019.03.063

Abstract: Primaquine (PMQ), a well-known anti-malarial drug, is of increasing importance as people moving toward global malaria eradication. PMQ has serious side effects that it often causes acute hemolytic toxicity in people with glucose-6-phosphate dehydrogenase (G6PD)… read more here.

Keywords: anti malarial; drug; malarial drug; reaction ... See more keywords

Non-Covalent Bonding Interaction between Primaquine as Guest and 2-(Hydroxypropyl)-β-Cyclodextrin as Host

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recommendations! Published in 2020 at "Polycyclic Aromatic Compounds"

DOI: 10.1080/10406638.2020.1813181

Abstract: An inclusion complex of Primaquine (PQ) with 2-(Hydroxypropyl)-β-Cyclodextrin (2-HP-β-CD) in liquid state have been investigated by using absorption and fluorescence spectral techniques. From the s... read more here.

Keywords: non covalent; covalent bonding; hydroxypropyl cyclodextrin; primaquine ... See more keywords
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Measurements of 5,6-Orthoquinone, a Surrogate for the Presumed Active Primaquine Metabolite 5-Hydroxyprimaquine, in the Urine of Cambodian Adults

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.01821-21

Abstract: The active metabolites of primaquine, in particular 5-hydroxyprimaquine, likely responsible for the clearance of dormant hypnozoites, are produced through the hepatic CYP450 2D6 (CYP2D6) enzymatic pathway. With the inherent instability of 5-hydroxyprimaquine, a stable surrogate,… read more here.

Keywords: cyp450 2d6; primaquine; orthoquinone detected; hydroxyprimaquine ... See more keywords

The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis

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recommendations! Published in 2019 at "Wellcome Open Research"

DOI: 10.12688/wellcomeopenres.15100.2

Abstract: Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group. If national malaria programs mandate daily primaquine dosing (the… read more here.

Keywords: g6pd; g6pd testing; case series; haemolysis ... See more keywords
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Single dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0168702

Abstract: Background Single low dose primaquine (SLD PQ, 0.25mg/kg) is recommended in combination with artemisinin-based combination therapy (ACT) as a gametocytocide to prevent Plasmodium falciparum transmission in areas threatened by artemisinin resistance. To date, no randomized… read more here.

Keywords: dhp; transmission; falciparum; dose primaquine ... See more keywords
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Evaluation of the CareStart™ glucose-6-phosphate dehydrogenase (G6PD) rapid diagnostic test in the field settings and assessment of perceived risk from primaquine at the community level in Cambodia

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recommendations! Published in 2020 at "PLoS ONE"

DOI: 10.1371/journal.pone.0228207

Abstract: Background Primaquine is an approved radical cure treatment for Plasmodium vivax malaria but treatment can result in life-threatening hemolysis if given to a glucose-6-phosphate dehydrogenase deficient (G6PDd) patient. There is a need for reliable point-of-care… read more here.

Keywords: staff; field; glucose phosphate; test ... See more keywords
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Pharmacogene Variation in Thai Plasmodium vivax Relapse Patients Treated with a Combination of Primaquine and Chloroquine

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recommendations! Published in 2020 at "Pharmacogenomics and Personalized Medicine"

DOI: 10.2147/pgpm.s201007

Abstract: Purpose Pharmacogenes have an influence on biotransformation pathway and clinical outcome of primaquine and chloroquine which are often prescribed to treat Plasmodium vivax infection. Genetic variation may impact enzyme activity and/or transporter function and thereby… read more here.

Keywords: relapse; variation; plasmodium vivax; primaquine ... See more keywords
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Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.1104735

Abstract: Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic… read more here.

Keywords: primaquine; metabolism; pharmacology; tolerability ... See more keywords

Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

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recommendations! Published in 2021 at "Molecules"

DOI: 10.3390/molecules26144357

Abstract: The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated. All samples were extracted using acetonitrile… read more here.

Keywords: plasma urine; determination primaquine; primaquine orthoquinone; orthoquinone primaquine ... See more keywords