Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation.
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DOI: 10.1016/j.dmpk.2018.08.004
Abstract: Cytochrome P450 2D6 (CYP2D6) is responsible for the metabolic activation of primaquine, an antimalarial drug. CYP2D6 is genetically polymorphic, and these polymorphisms are associated with interindividual variations observed in the therapeutic efficacy of primaquine. To… read more here.
Keywords: cyp2d6 allelic; cyp2d6; allelic variants; primaquine hydroxylation ... See more keywords