Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c03936
Abstract: Microtubule targeting agents (MTAs) have been used for the treatment of cancer for many decades and are among the most successful chemotherapeutic agents. However, their application and effectiveness are limited because of toxicity and resistance… read more here.
Keywords: death; leukemia cells; lymphoblastic leukemia; primary acute ... See more keywords
Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase
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DOI: 10.1080/15384101.2018.1496746
Abstract: ABSTRACT We recently reported that primary acute lymphoblastic leukemia (ALL) cells are susceptible to the microtubule depolymerizing agent vincristine (VCR) in G1 phase. This finding prompted testing another G1 phase-active compound, palbociclib (PCB), a highly… read more here.
Keywords: phase; lymphoblastic leukemia; primary acute; acute lymphoblastic ... See more keywords
Programmed Death Ligand-1 is Frequently Expressed in Primary Acute Myeloid Leukemia and B-Acute Lymphoblastic Leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2021.210701
Abstract: BACKGROUND The introduction of checkpoint inhibitors in solid cancer therapy showed successful results. The role of Programmed Death-1/Programmed Death-Ligand 1 (PD1/PD-L1) in hematologic malignancies is currently being investigated and clinical trials are ongoing. Preliminary findings… read more here.
Keywords: primary acute; programmed death; leukemia; death ligand ... See more keywords