Glutamate in primary afferents is required for itch transmission
Sign Up to like & getrecommendations! Published in 2022 at "Neuron"
DOI: 10.1016/j.neuron.2021.12.007
Abstract: Whether glutamate or itch-selective neurotransmitters are used to confer itch specificity is still under debate. We focused on an itch-selective population of primary afferents expressing MRGPRA3, which highly expresses Vglut2 and the neuropeptide neuromedin B… read more here.
Keywords: mrgpra3 afferents; itch transmission; primary afferents; glutamate primary ... See more keywords
Local translation in primary afferents and its contribution to pain.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002658
Abstract: ABSTRACT Chronic pain remains a significant problem due to its prevalence, impact, and limited therapeutic options. Progress in addressing chronic pain is dependent on a better understanding of underlying mechanisms. While the available evidence suggests… read more here.
Keywords: signaling molecules; local translation; primary afferents; chronic pain ... See more keywords