Expansion and intensification of humoral autoimmune response in the transition from preclinical to full‐blown primary biliary cholangitis
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DOI: 10.1002/hep.29260
Abstract: We read with interest the article by Dahlqvist et al. about individuals with anti-mitochondria antibodies (AMAs) and nonestablished primary biliary cholangitis (PBC). The fortuitous finding of a positive AMA test in patients with no clinical… read more here.
Keywords: primary biliary; pbc; ama positive; humoral autoimmune ... See more keywords
Evolving role of obeticholic acid in primary biliary cholangitis
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DOI: 10.1002/hep.29726
Abstract: Primary biliary cholangitis (PBC) is an immunemediated cholestatic liver disease characterized by destruction of the small intrahepatic bile ducts; if left untreated, persistent inflammation and cholestasis lead to biliary cirrhosis and end-stage liver disease. Although… read more here.
Keywords: primary biliary; pbc; receptor; biliary cholangitis ... See more keywords
Primary biliary cholangitis, DNA, and beyond: The Relative contribution of genes
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DOI: 10.1002/hep.29783
Abstract: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by immune-mediated damage to biliary epithelial cells resulting in inflammation, progressive fibrosis, cirrhosis, and liver failure. While its precise etiopathogenesis remains unclear, the disease… read more here.
Keywords: primary biliary; risk; pbc; disease ... See more keywords
Letter to the Editor: Are We Confident That Primary Biliary Cholangitis Liver‐Related Mortality Is Higher in Males?
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DOI: 10.1002/hep.31882
Abstract: We read with interest the recent communication reporting the prognostic impact of male sex in patients with primary biliary cholangitis (PBC) and well-compensated cirrhosis. The work raises important questions for clinicians managing PBC. read more here.
Keywords: primary biliary; editor confident; confident primary; biliary cholangitis ... See more keywords
Letter to the Editor: Is Male Sex Associated With Increased Liver‐Related Mortality in Primary Biliary Cholangitis and Cirrhosis?
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DOI: 10.1002/hep.31916
Abstract: We read with great interests the study by Dr. John et al. In this retrospective study using national data on USA Veterans, multivariate competing risk analysis identified that male gender was independently associated with a… read more here.
Keywords: liver related; primary biliary; cirrhosis; biliary cholangitis ... See more keywords
Response to "Is Male Gender Associated with Increased Liver-related Mortality in Primary Biliary Cholangitis and Cirrhosis?"
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DOI: 10.1002/hep.31917
Abstract: We thank Sun and colleagues for their interest in our paper. While our study cohort is not derived from the general population, the proportion of males (78.4%) in our cohort of Primary biliary cholangitis (PBC)… read more here.
Keywords: response male; biliary cholangitis; primary biliary; cirrhosis ... See more keywords
Mechanisms and molecules: What are the treatment targets for primary biliary cholangitis?
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DOI: 10.1002/hep.32405
Abstract: Treatment of primary biliary cholangitis (PBC) with ursodeoxycholic acid (UDCA) is not always sufficient to prevent progression to hepatic decompensation and/or need for liver transplant. Adjuvant therapy with obeticholic acid may provide additional biochemical improvements… read more here.
Keywords: cell; mechanisms molecules; primary biliary; biliary cholangitis ... See more keywords
IL‐17A produced by invariant natural killer T cells and CD3+CD56+αGalcer‐CD1d tetramer– T cells promote liver fibrosis in patients with primary biliary cholangitis
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DOI: 10.1002/jlb.2a0622-586rrrr
Abstract: Primary biliary cholangitis (PBC) is characterized as interlobular bile duct injury and fibrosis, which results from the loss of tolerance to self‐antigens. However, the exact pathologic mechanism leading to injury and fibrosis in PBC patients… read more here.
Keywords: cd56 galcer; primary biliary; pbc patients; biliary cholangitis ... See more keywords
The latest research trends in primary biliary cholangitis: a bibliometric analysis
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DOI: 10.1007/s10238-022-00825-0
Abstract: The bibliometric analysis uses the citation count of an article to measure its impact in the scientific community, but no study has been undertaken to determine the most influential papers in the field of primary… read more here.
Keywords: bibliometric analysis; primary biliary; research; biliary cholangitis ... See more keywords
Gender and Racial Differences in Hospitalizations for Primary Biliary Cholangitis in the USA
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DOI: 10.1007/s10620-020-06402-3
Abstract: The prevalence, characteristics, burden and trends of primary biliary cholangitis (PBC) hospitalizations in the USA remain unclear. We identified primary PBC hospitalizations from the National Inpatient Sample (NIS) 2007 through 2014 using ICD-9-CM codes. We… read more here.
Keywords: primary biliary; pbc hospitalizations; racial minorities; pbc ... See more keywords
Anti-mitochondrial Antibody-Negative Primary Biliary Cholangitis Is Part of the Same Spectrum of Classical Primary Biliary Cholangitis
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DOI: 10.1007/s10620-021-07122-y
Abstract: Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease in which anti-mitochondrial antibodies (AMA) are the diagnostic hallmark. Whether AMA-negative PBC patients represent a different phenotype of disease is highly debated. The purpose of… read more here.
Keywords: primary biliary; pbc; ama negative; negative pbc ... See more keywords