Carboxylic Acid Directed γ-Lactonization of Unactivated Primary C–H Bonds Catalyzed by Mn Complexes: Application to Stereoselective Natural Product Diversification
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DOI: 10.1021/jacs.2c08620
Abstract: Reactions that enable selective functionalization of strong aliphatic C–H bonds open new synthetic paths to rapidly increase molecular complexity and expand chemical space. Particularly valuable are reactions where site-selectivity can be directed toward a specific… read more here.
Keywords: carboxylic acid; unactivated primary; lactonization; primary bonds ... See more keywords
Activation of Primary C-H Bonds in Oxidative Cyclizations of Tambjamines Catalyzed by Rieske Oxygenases TamC and PtTamC.
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DOI: 10.1021/jacs.4c17468
Abstract: Tambjamines are complex bipyrrole-containing natural products that possess promising bioactive properties. Although Pseudoalteromonas citrea is known to produce both cyclic tambjamine MYP1 and the linear precursor (YP1), the biosynthetic machinery used to catalyze the site-selective… read more here.
Keywords: rieske; tamc pttamc; oxidative cyclizations; primary bonds ... See more keywords