Valsartan Regulates PI3K/AKT Pathways through lncRNA GASL1 to Improve Isoproterenol-Induced Heart Failure
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DOI: 10.1155/2022/1447399
Abstract: Objective This study is aimed at determining the expression and function of the GASL1 and PI3K/AKT pathways in isoproterenol- (ISO-) induced heart failure (HF). To determine the moderating effect of valsartan (VAL) on the progression… read more here.
Keywords: primary cardiomyocytes; pi3k akt; gasl1; iso induced ... See more keywords
Ferroptosis-Specific Inhibitor Ferrostatin-1 Relieves H2O2-Induced Redox Imbalance in Primary Cardiomyocytes through the Nrf2/ARE Pathway
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DOI: 10.1155/2022/4539932
Abstract: Objective Ischemic heart disease (IHD) has always been the focus of attention of many researchers in cardiovascular disease, and its pathogenesis is also very complicated. Ferroptosis may be involved in the occurrence and development of… read more here.
Keywords: ferroptosis specific; nrf2 pathway; inhibitor ferrostatin; primary cardiomyocytes ... See more keywords
The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics
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DOI: 10.1242/jcs.221606
Abstract: ABSTRACT The junctional complexes that couple cardiomyocytes must transmit the mechanical forces of contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects the actomyosin networks of neighboring cardiomyocytes and is required for proper heart… read more here.
Keywords: interactome primary; cadherin interactome; primary cardiomyocytes; proximity proteomics ... See more keywords