Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25326
Abstract: Loss of retinal ganglion cells (RGCs) underlies several forms of retinal disease including glaucomatous optic neuropathy, a leading cause of irreversible blindness. Several rare genetic disorders associated with cilia dysfunction have retinal degeneration as a… read more here.
Keywords: rgc cilia; cilia markers; ganglion cells; retinal ganglion ... See more keywords
Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC‐1 and BORC complexes
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22542
Abstract: The biogenesis of lysosome‐related organelles complex‐1 (BLOC‐1) and the bloc‐one‐related complex (BORC) are the cytosolic protein complexes required for specialized membrane protein traffic along the endocytic route and the spatial distribution of endosome‐derived compartments, respectively.… read more here.
Keywords: bloc; bloc borc; primary cilia; membrane ... See more keywords
Primary Cilia Direct Murine Articular Cartilage Tidemark Patterning Through Hedgehog Signaling and Ambulatory Load
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4506
Abstract: Articular cartilage (AC) is essential for body movement but is highly susceptible to degenerative diseases and has poor self‐repair capacity. To improve current subpar regenerative treatments, developmental mechanisms of AC should be clarified and, specifically,… read more here.
Keywords: hedgehog signaling; tidemark; tidemark patterning; load ... See more keywords
PDGF‐AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30345
Abstract: Testes control the development of male reproductive system. The testicular interstitial Leydig cells (Leydig cells) synthesize testosterone for promoting spermatogenesis and secondary sexual characteristics. Type A platelet‐derived growth factor (PDGF‐AA) is one of the most… read more here.
Keywords: growth; leydig; leydig cell; akt erk ... See more keywords
Crosstalk between the COX2‐PGE2‐EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30198
Abstract: Primary cilia have been found to function as mechanosensors in low‐magnitude high‐frequency vibration (LMHFV)‐induced osteogenesis. The PGE2 also regulates bone homeostasis and mechanical osteogenesis through its receptor EP4 signaling, but its involvement in LMHFV‐induced or… read more here.
Keywords: cox2 pge2; ep4 signaling; lmhfv; primary cilia ... See more keywords
PTH1R translocation to primary cilia in mechanically‐stimulated ostecytes prevents osteoclast formation via regulation of CXCL5 and IL‐6 secretion
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30849
Abstract: Osteocytes respond to mechanical forces controlling osteoblast and osteoclast function. Mechanical stimulation decreases osteocyte apoptosis and promotes bone formation. Primary cilia have been described as potential mechanosensors in bone cells. Certain osteogenic responses induced by… read more here.
Keywords: pth1r; mechanically stimulated; cxcl5; mlo ... See more keywords
Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation.
Sign Up to like & getrecommendations! Published in 2019 at "Protoplasma"
DOI: 10.1007/s00709-019-01385-z
Abstract: In animal cells, the centrosome nucleates and anchors microtubules (MT), forming their radial array. During interphase centrosome-derived MT, aster can either team up with other MT network or function in an autonomous manner. What is… read more here.
Keywords: centrosome; formation; pcm; centrosome derived ... See more keywords
Primary cilia-dependent signaling is involved in regulating mesenchymal stem cell proliferation and pluripotency maintenance
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-020-09876-7
Abstract: Using a large-scale quantitative mesenchymal stem cells (MSCs) membrane proteomics analysis, we identified a large group of ciliary proteins in the MSCs membrane fraction, which prompted us to examine the cilia, intricate organelles that were… read more here.
Keywords: cilia dependent; proliferation; mesenchymal stem; primary cilia ... See more keywords
Calcium–axonemal microtubuli interactions underlie mechanism(s) of primary cilia morphological changes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biological Physics"
DOI: 10.1007/s10867-017-9475-2
Abstract: We have used cell culture of astrocytes aligned within microchannels to investigate calcium effects on primary cilia morphology. In the absence of calcium and in the presence of flow of media (10 μL.s−1) the majority (90%)… read more here.
Keywords: microtubule; morphological changes; primary cilia; axonemal microtubuli ... See more keywords
Primary cilia in hard tissue development and diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of Medicine"
DOI: 10.1007/s11684-021-0829-6
Abstract: Bone and teeth are hard tissues. Hard tissue diseases have a serious effect on human survival and quality of life. Primary cilia are protrusions on the surfaces of cells. As antennas, they are distributed on… read more here.
Keywords: tissue development; cilia hard; hard tissue; primary cilia ... See more keywords
Freeing the brake: Proliferation needs primary cilium to disassemble
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-00090-x
Abstract: Primary cilia are non-motile, microtubule-based, antennae-like organelle that protrude out from the cell surface and perform sensory function or transduce physiological signals in majority of the vertebrate cells. Cilia are assembled on basal bodies that… read more here.
Keywords: cilia may; proliferation; brake proliferation; proliferation needs ... See more keywords