Bone Deterioration in Response to Chronic High‐Altitude Hypoxia Is Attenuated by a Pulsed Electromagnetic Field Via the Primary Cilium/HIF‐1α Axis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4772
Abstract: Chronic high‐altitude hypoxia induces irreversible abnormalities in various organisms. Emerging evidence indicates that hypobaric hypoxia markedly suppresses bone mass and bone strength. However, few effective means have been identified to prevent such bone deficits. Here,… read more here.
Keywords: hypoxia; bone; primary cilium; high altitude ... See more keywords
Primary cilium alterations and expression changes of Patched1 proteins in niemann‐pick type C disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25926
Abstract: Niemann‐Pick type C disease (NPC) is a disorder characterized by abnormal intracellular accumulation of unesterified cholesterol and glycolipids. Two distinct disease‐causing genes have been isolated, NPC1 and NPC2. The NPC1 protein is involved in the… read more here.
Keywords: disease; pick type; expression; type disease ... See more keywords
Routes and machinery of primary cilium biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2570-5
Abstract: Primary cilia are solitary, microtubule-based protrusions of the cell surface that play fundamental roles as photosensors, mechanosensors and biochemical sensors. Primary cilia dysfunction results in a long list of developmental and degenerative disorders that combine… read more here.
Keywords: machinery primary; epithelial cells; routes machinery; cilium ... See more keywords
Cyclic AMP does double duty to support parallel signaling in primary cilium and cytosol.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102436
Abstract: The primary cilium maintains all of the necessary machinery to generate and interpret cAMP signals within its tiny volume, leading to the supposition that ciliary cAMP provides unique biological instructions separate from those derived from… read more here.
Keywords: cilium; cyclic amp; amp double; duty support ... See more keywords
Primary cilia are required for the persistence of memory and stabilization of perineuronal nets
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102617
Abstract: Summary It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales. Early mechanisms of memory formation (synaptic consolidation) have been extensively characterized. However, delayed mechanisms, which… read more here.
Keywords: required persistence; primary cilia; primary cilium; memory ... See more keywords
The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activation.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101799
Abstract: The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues and regulate cellular functions, including cell migration. The migration of mesenchymal stem cells (MSCs) to bone remodeling… read more here.
Keywords: cilium; cd44; migration; activation ... See more keywords
The primary cilium is necessary for the differentiation and the maintenance of human adipose progenitors into myofibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15649-2
Abstract: The primary cilium is an organelle, present at the cell surface, with various biological functions. We, and others, have shown that it plays a role in the differentiation of adipose progenitors (APs) into adipocytes. APs… read more here.
Keywords: cilium necessary; cilium; adipose progenitors; necessary differentiation ... See more keywords
Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling-dependent neurogenesis in the embryonic neural tube.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220037120
Abstract: The balance between neural stem cell proliferation and neuronal differentiation is paramount for the appropriate development of the nervous system. Sonic hedgehog (Shh) is known to sequentially promote cell proliferation and specification of neuronal phenotypes,… read more here.
Keywords: cell; hedgehog; cell primary; primary cilium ... See more keywords
Fluid flow-induced shear stress controls the metabolism of proximal tubule kidney epithelial cells through primary cilium-dependent lipophagy and mitochondria biogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1823125
Abstract: ABSTRACT The kidney, similar to many other organs, has to face shear stress induced by biological fluids. How epithelial kidney cells respond to shear stress is poorly understood. Recently we showed in vitro and in… read more here.
Keywords: epithelial cells; shear stress; proximal tubule; stress ... See more keywords
Trafficking to the primary cilium membrane
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-07-0505
Abstract: The primary cilium has been found to be associated with a number of cellular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis of diseases affecting multiple organs, including the neural tube,… read more here.
Keywords: ciliary membrane; ciliary compartmentalization; cilium; primary cilium ... See more keywords
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abb0601
Abstract: Newborn neurons assemble a new primary cilium, leading to a change in the mode of Shh signaling that now directs axon extension. Cellular differentiation leads to the formation of specialized cell types and complex morphological… read more here.
Keywords: cilium; differentiating neurons; mediates cell; cilium remodeling ... See more keywords