Combined Flow‐Fluorescence in situ hybridization to HHV‐8 and EBV reveals the viral heterogeneity of primary effusion lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29836
Abstract: Primary effusion lymphoma (PEL) is a rare B‐cell non‐Hodgkin lymphoma associated with Kaposi Sarcoma‐associated herpesvirus (KSHV/HHV8) infection. Lymphoma cells are coinfected with Epstein‐Barr virus (EBV) in 60−80% of cases. Tools allowing a reliable PEL diagnosis… read more here.
Keywords: primary effusion; effusion lymphoma; fluorescence situ; flow fluorescence ... See more keywords
Heterogeneous Activation of Signaling Pathways and Therapeutic Vulnerabilities in KSHV‐Associated Primary Effusion Lymphoma Cell Lines
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70534
Abstract: Primary effusion lymphoma (PEL) is a rare and aggressive B‐cell malignancy caused by Kaposi's sarcoma‐associated herpesvirus (KSHV), with limited treatment options and poor prognosis. KSHV‐encoded proteins and miRNAs activate multiple signaling pathways that promote cell… read more here.
Keywords: signaling pathways; cell lines; primary effusion; activation ... See more keywords
ROS mediated apoptotic pathways in primary effusion lymphoma: Comment on induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic pathways in primary effusion lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101061
Abstract: Highlights • Mechanism of action of Shikonin against PEL.• Therapeutic potential of Shikonin as an alternative herbal medicine.• Interconnectivity among cellular stress, apoptosis pathways (extrinsic and intrinsic) and Shikonin. read more here.
Keywords: pathways primary; ros mediated; shikonin; primary effusion ... See more keywords
Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-20136-w
Abstract: Primary effusion lymphoma (PEL) has a very poor prognosis. To evaluate the contributions of enhancers/promoters interactions to PEL cell growth and survival, here we produce H3K27ac HiChIP datasets in PEL cells. This allows us to… read more here.
Keywords: enhancer connectome; dependency factors; connectome links; primary effusion ... See more keywords
Inhibition of MCL1 induces apoptosis in anaplastic large cell lymphoma and in primary effusion lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-04916-6
Abstract: Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignancies and contributes to tumorigenesis by inhibiting the apoptotic machinery of the cells. Antagonizing BH3 mimetics provide an option for medication, with venetoclax as the… read more here.
Keywords: cell lymphoma; primary effusion; lymphoma; anaplastic large ... See more keywords
Human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma presenting with cardiac tamponade
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000008010
Abstract: Rationale: Primary effusion lymphoma (PEL) is a rare disease of lymphomatous effusion in the body cavities in the absence of detectable mass and lymphadenopathy. PEL is predominantly related to the immunosuppressed patients infected with human… read more here.
Keywords: lymphoma; like lymphoma; primary effusion; effusion lymphoma ... See more keywords
Cutaneous Extracavitary Primary Effusion Lymphoma: A Case Report and Review of Literature.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of cutaneous pathology"
DOI: 10.1111/cup.70007
Abstract: Primary effusion lymphoma (PEL) is a rare B‐cell lymphoma that is most often seen in immunocompromised patients with human herpesvirus‐8 (HHV‐8) and Epstein–Barr virus (EBV) infections. PEL typically affects body cavities with occasional involvement of… read more here.
Keywords: primary effusion; cutaneous extracavitary; effusion lymphoma; case ... See more keywords
Rapidly progressive intravascular primary effusion lymphoma in an HIV‐positive renal transplant recipient
Sign Up to like & getrecommendations! Published in 2018 at "Histopathology"
DOI: 10.1111/his.13347
Abstract: We describe the clinical and post‐mortem findings of a case of rapidly progressive, ultimately fatal primary effusion lymphoma (PEL) arising in an HIV‐positive man 2 years after renal transplantation. Disseminated multi‐organ involvement associated with a… read more here.
Keywords: lymphoma; rapidly progressive; primary effusion; effusion lymphoma ... See more keywords
HIV‐negative primary effusion lymphoma: a series of seven cases
Sign Up to like & getrecommendations! Published in 2025 at "Histopathology"
DOI: 10.1111/his.15446
Abstract: Primary effusion lymphoma (PEL) is a rare aggressive, human herpesvirus‐8 (HHV8)‐associated neoplasm of post‐germinal centre B cell origin. It usually presents as a serous effusion in human immunodeficiency virus (HIV)‐positive patients. PEL is rarely reported… read more here.
Keywords: effusion; primary effusion; hiv negative; effusion lymphoma ... See more keywords
Primary effusion lymphoma of the pleural space: Report of a rare complication of cardiac transplant with review of the literature
Sign Up to like & getrecommendations! Published in 2019 at "Transplant Infectious Disease"
DOI: 10.1111/tid.13005
Abstract: Primary effusion lymphoma (PEL) is a rare mature B‐cell non‐Hodgkin’s lymphoma arising in body cavities and presenting with effusions. It has been described predominantly in patients with impaired immunity from the acquired immunodeficiency syndrome and… read more here.
Keywords: effusion lymphoma; transplant; report; primary effusion ... See more keywords
Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01360-22
Abstract: Primary effusion lymphoma (PEL) is caused by Kaposi’s sarcoma-associated herpesvirus. We showed previously that PEL cell lines require the antiapoptotic protein MCL1 for survival but not the other BCL2 family proteins. ABSTRACT Kaposi’s sarcoma-associated herpesvirus… read more here.
Keywords: bcl2 family; mcl1; family; primary effusion ... See more keywords