Designing superiority trials with window mean survival time as a primary endpoint.
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in medicine"
DOI: 10.1002/sim.9738
Abstract: Window mean survival time (WMST), a simple extension of restricted mean survival time (RMST), allows for clinicians to evaluate the mean survival difference between treatment groups in specific windows of time during the follow-up period… read more here.
Keywords: time; primary endpoint; mean survival; window mean ... See more keywords
Underpowered or negative? A crucial distinction
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4853-x
Abstract: To the Editor: Schrauwen and colleagues have recently reviewed the emerging field of NAD metabolism in Diabetologia [1]. Their manuscript includes a description of a clinical trial of dietary nicotinamide riboside supplementation effects on whole… read more here.
Keywords: trial; value; study; nicotinamide riboside ... See more keywords
Antithrombotic strategies in elderly patients with atrial fibrillation revascularized with drug-eluting stents: PACO-PCI (EPIC-15) registry.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2021.05.036
Abstract: BACKGROUND We sought to investigate the antithrombotic regimens applied and their prognostic effects in patients over 75 years old with atrial fibrillation (AF) after revascularization with drug-eluting stents (DES). METHODS Retrospective registry in 20 centers including… read more here.
Keywords: atrial fibrillation; drug eluting; eluting stents; macce ... See more keywords
Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2020.12.052
Abstract: BACKGROUND In low surgical risk patients with symptomatic severe aortic stenosis, the PARTNER 3 (Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis) trial demonstrated superiority of… read more here.
Keywords: risk; surgery; tavr; primary endpoint ... See more keywords
Knowledge about atrial fibrillation and anticoagulation affects the risk of clinical outcomes.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis research"
DOI: 10.1016/j.thromres.2022.03.011
Abstract: BACKGROUND Knowledge about atrial fibrillation (AF) and oral anticoagulation (OAC) is insufficient among AF patients. OBJECTIVE We examined the association between this knowledge and event rate. METHODS We studied 174 anticoagulated patients with AF aged… read more here.
Keywords: knowledge atrial; atrial fibrillation; knowledge; anticoagulation ... See more keywords
The importance of association of comorbidities on COVID-19 outcomes: a machine learning approach
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2029382
Abstract: Abstract Background The individual influence of a variety of comorbidities on COVID-19 patient outcomes has already been analyzed in previous works in an isolated way. We aim to determine if different associations of diseases influence… read more here.
Keywords: comorbidities covid; primary endpoint; machine learning; association comorbidities ... See more keywords
Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment.
Sign Up to like & getrecommendations! Published in 2022 at "Biostatistics"
DOI: 10.1093/biostatistics/kxac040
Abstract: For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints (CEs) are widely chosen as the primary endpoint. Despite being commonly used, CEs entail challenges in designing… read more here.
Keywords: sample size; primary endpoint; endpoint; trial ... See more keywords
Electrocardiographic characteristics and associated outcomes in patients with Takotsubo syndrome. Insights from the RETAKO registry
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.1816
Abstract: Our aim was to describe the prevalence and prognostic significance of electrocardiographic features in patients with Takotsubo syndrome (TTS). Our data come from the Spanish Multicenter REgistry of TAKOtsubo syndrome (RETAKO). All patients with complete… read more here.
Keywords: electrocardiographic characteristics; cause death; takotsubo syndrome; primary endpoint ... See more keywords
Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial
Sign Up to like & getrecommendations! Published in 2022 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehac374
Abstract: Abstract Aims In a retrospective analysis of dal-Outcomes, the effect of dalcetrapib on cardiovascular events was influenced by an adenylate cyclase type 9 (ADCY9) gene polymorphism. The dal-GenE study was conducted to test this pharmacogenetic… read more here.
Keywords: primary endpoint; dal gene; trial; dalcetrapib ... See more keywords
Physical activity and exercise capacity as composite versus single categorical endpoints for trials of exercise-based cardiac rehabilitation interventions: comparison of sample size requirements
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Preventive Cardiology"
DOI: 10.1093/eurjpc/zwad125.304
Abstract: Type of funding sources: None. A composite primary endpoint consists of two or more component endpoints, events or outcomes. If any one of these is observed, it is considered that the composite primary endpoint has… read more here.
Keywords: sample size; primary endpoint; endpoint; exercise capacity ... See more keywords
Differential predictive factors for cardiovascular events in patients with or without cancer history
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017602
Abstract: Supplemental Digital Content is available in the text Abstract Although attention has been paid to the relationship between malignant diseases and cardiovascular diseases, few data have been reported. Moreover, there have also been few reports… read more here.
Keywords: patients without; primary endpoint; cardiovascular events; disease ... See more keywords