A multiple testing framework for diagnostic accuracy studies with co‐primary endpoints
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9308
Abstract: Major advances have been made regarding the utilization of machine learning techniques for disease diagnosis and prognosis based on complex and high‐dimensional data. Despite all justified enthusiasm, overoptimistic assessments of predictive performance are still common… read more here.
Keywords: primary endpoints; accuracy studies; model; testing framework ... See more keywords
Adoption of multiple primary endpoints in phase III trials of systemic treatments in patients with advanced solid tumours. A systematic review.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of cancer"
DOI: 10.1016/j.ejca.2021.03.007
Abstract: BACKGROUND AND AIM Trial designs using multiple primary endpoints (MPEs) are increasing in phase III cancer trials. Our objectives were to describe the incidence of MPEs in recently published phase III trials testing systemic treatments in… read more here.
Keywords: iii trials; patients advanced; phase iii; primary endpoints ... See more keywords
Demonstration of an anti‐hyperalgesic effect of a novel pan‐Trk inhibitor PF‐06273340 in a battery of human evoked pain models
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13448
Abstract: AIM Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin-related kinase (Trk) family and the unrelated p75 receptor. PF-06273340 is a small… read more here.
Keywords: pan trk; trk inhibitor; inhibitor; primary endpoints ... See more keywords
Sample size determination for a specific region in multiregional clinical trials with multiple co-primary endpoints
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DOI: 10.1371/journal.pone.0180405
Abstract: Recently, multi-regional clinical trials (MRCTs), which incorporate subjects from many countries/regions around the world under the same protocol, have been widely conducted by many global pharmaceutical companies. The objective of such trials is to accelerate… read more here.
Keywords: multiple primary; primary endpoints; specific region; clinical trials ... See more keywords