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Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9308
Abstract: Major advances have been made regarding the utilization of machine learning techniques for disease diagnosis and prognosis based on complex and high‐dimensional data. Despite all justified enthusiasm, overoptimistic assessments of predictive performance are still common…
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Keywords:
primary endpoints;
accuracy studies;
model;
testing framework ... See more keywords
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Published in 2021 at "European journal of cancer"
DOI: 10.1016/j.ejca.2021.03.007
Abstract: BACKGROUND AND AIM Trial designs using multiple primary endpoints (MPEs) are increasing in phase III cancer trials. Our objectives were to describe the incidence of MPEs in recently published phase III trials testing systemic treatments in…
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Keywords:
iii trials;
patients advanced;
phase iii;
primary endpoints ... See more keywords
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Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13448
Abstract: AIM Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin-related kinase (Trk) family and the unrelated p75 receptor. PF-06273340 is a small…
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Keywords:
pan trk;
trk inhibitor;
inhibitor;
primary endpoints ... See more keywords
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Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180405
Abstract: Recently, multi-regional clinical trials (MRCTs), which incorporate subjects from many countries/regions around the world under the same protocol, have been widely conducted by many global pharmaceutical companies. The objective of such trials is to accelerate…
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Keywords:
multiple primary;
primary endpoints;
specific region;
clinical trials ... See more keywords