Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
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DOI: 10.1021/acs.biochem.9b00051
Abstract: Primary hyperaldosteronism (Conn's syndrome), a common cause of secondary hypertension, is frequently produced by unilateral aldosterone-producing adenomas that carry mutations in ion-transporting genes, including ATP1A1, encoding the Na/K pump's α1 subunit. Whether Na/K pump mutant-mediated… read more here.
Keywords: hyperaldosteronism; pump; primary hyperaldosteronism; inward currents ... See more keywords
Ten-year outcomes in patients with hypertension and primary hyperaldosteronism undergoing surgical adrenalectomy versus medical therapy: data from the multinational collaborative network TriNetX
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.2530
Abstract: Surgical adrenalectomy for resection of adenomas has been the standard approach for treating patients with secondary hypertension due to primary hyperaldosteronism. However, few studies explored long-term outcomes in patients treated with adrenalectomy when compared to… read more here.
Keywords: surgical adrenalectomy; medical therapy; primary hyperaldosteronism;
CARDIOVASCULAR AND GLUCO-METABOLIC COMPLICATIONS IN PATIENTS WITH PRIMARY HYPERALDOSTERONISM
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DOI: 10.1097/01.hjh.0000837516.62087.d7
Abstract: Objective: Primary hyperaldosteronism (PA) is an under-diagnosed cause of hypertension. The presentation is classically known to occur in a patient with hypertension and hypokalemia. However, in reality, most patients will present without hyperkalemia. PA is… read more here.
Keywords: metabolic complications; hypertension; risk; primary hyperaldosteronism ... See more keywords
Abstract P2024: Treatment of Primary Hyperaldosteronism Increases Plasma Epoxyeicosatrienoic Acids
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2024
Abstract: Epoxyeicosatrienoic acids (EETs) are lipid signaling molecules formed from arachidonic acid by the action of CYP450s. EETs cause vasodilation, exert anti-inflammatory effects, and enhance insulin secretion and sensitivity. 14,15-DHET has been reported to be increased… read more here.
Keywords: eet; hyperaldosteronism; treatment primary; primary hyperaldosteronism ... See more keywords
Abstract FR602: Prevalence and Predictors of Screening for Primary Hyperaldosteronism in Adults with Hypertension
Sign Up to like & getrecommendations! Published in 2025 at "Hypertension"
DOI: 10.1161/hyp.82.suppl_1.fr602
Abstract: Introduction: Primary hyperaldosteronism (PA) is a treatable, frequently underdiagnosed cause of secondary hypertension. We sought to characterize a target population for an intervention to increase appropriate screening for PA, with the hypothesis that a significant… read more here.
Keywords: primary hyperaldosteronism; adults hypertension; medicine; hypertension ... See more keywords
Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x221135124
Abstract: Case series summary Twenty-nine cats from different institutions with confirmed or highly suspected primary hyperaldosteronism treated by unilateral adrenalectomy were retrospectively included in this study. The most frequent clinical signs were lethargy (n = 20; 69%) and… read more here.
Keywords: hyperaldosteronism; unilateral adrenalectomy; primary hyperaldosteronism; adrenalectomy ... See more keywords
6447 Delayed Presentation Of Primary Hyperaldosteronism In The Setting Of An Adrenal Incidentaloma
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DOI: 10.1210/jendso/bvae163.165
Abstract: Abstract Disclosure: S.K. Devineni: None. J.L. Gilden: None. Background: Current guidelines for biochemical monitoring in the setting of an adrenal incidentaloma suggest annual laboratory testing up to 4 years. If there is no progression in… read more here.
Keywords: primary hyperaldosteronism; adrenal incidentaloma; presentation; history ... See more keywords
SUN-401 Discordant Findings on AVS and CT in a Patient with Primary Hyperaldosteronism: Trusting Biochemical Data for Accurate Diagnosis
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DOI: 10.1210/jendso/bvaf149.374
Abstract: Abstract Disclosure: A. Attre: None. P. Sztachelski: None. A. Arigala: None. B. Esayag-Tendler: None. Introduction: Primary Hyperaldosteronism (PA) is a leading cause of secondary hypertension amenable to specific therapy. We describe a case of PA… read more here.
Keywords: avs; none; primary hyperaldosteronism; biochemical data ... See more keywords
SAT-072 Recurrent Hypokalemic Paralysis: A Case Of Delayed Diagnosis Of Primary Hyperaldosteronism
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-072
Abstract: Abstract Introduction: Acute hypokalemic paralysis is a relatively rare, potentially life threatening but treatable cause of acute myopathy. Rapid diagnosis with appropriate treatment is critical. Herein, we present a case of hypokalemic paralysis due to… read more here.
Keywords: paralysis; hypokalemic paralysis; case; primary hyperaldosteronism ... See more keywords
ASO Author Reflections: Predicting Postoperative Resolution of Hypertension in Primary Hyperaldosteronism
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DOI: 10.1245/s10434-021-09762-w
Abstract: While hypokalemia routinely normalizes after unilateral adrenalectomy for primary hyperaldosteronism (PA), only one-third of patients will achieve postoperative normotension, and our ability to preoperatively identify those who will become normotensive remains both a priority and… read more here.
Keywords: resolution; hyperaldosteronism; author reflections; primary hyperaldosteronism ... See more keywords
Topical Diagnosis and Determination of the Primary Hyperaldosteronism Variant
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DOI: 10.25122/jml-2019-0072
Abstract: Laboratory diagnosis of primary hyperaldosteronism is based on determining blood levels of aldosterone, renin on request, potassium, and sodium. The results of these studies are significantly influenced by drugs, preparation for the study and blood… read more here.
Keywords: diagnosis; primary hyperaldosteronism; determination primary; topical diagnosis ... See more keywords