Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
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DOI: 10.1021/acs.biochem.9b00051
Abstract: Primary hyperaldosteronism (Conn's syndrome), a common cause of secondary hypertension, is frequently produced by unilateral aldosterone-producing adenomas that carry mutations in ion-transporting genes, including ATP1A1, encoding the Na/K pump's Ī±1 subunit. Whether Na/K pump mutant-mediated… read more here.
Keywords: hyperaldosteronism; pump; primary hyperaldosteronism; inward currents ... See more keywords
CARDIOVASCULAR AND GLUCO-METABOLIC COMPLICATIONS IN PATIENTS WITH PRIMARY HYPERALDOSTERONISM
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DOI: 10.1097/01.hjh.0000837516.62087.d7
Abstract: Objective: Primary hyperaldosteronism (PA) is an under-diagnosed cause of hypertension. The presentation is classically known to occur in a patient with hypertension and hypokalemia. However, in reality, most patients will present without hyperkalemia. PA is… read more here.
Keywords: metabolic complications; hypertension; risk; primary hyperaldosteronism ... See more keywords
Abstract P2024: Treatment of Primary Hyperaldosteronism Increases Plasma Epoxyeicosatrienoic Acids
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DOI: 10.1161/hyp.74.suppl_1.p2024
Abstract: Epoxyeicosatrienoic acids (EETs) are lipid signaling molecules formed from arachidonic acid by the action of CYP450s. EETs cause vasodilation, exert anti-inflammatory effects, and enhance insulin secretion and sensitivity. 14,15-DHET has been reported to be increased… read more here.
Keywords: eet; hyperaldosteronism; treatment primary; primary hyperaldosteronism ... See more keywords
Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x221135124
Abstract: Case series summary Twenty-nine cats from different institutions with confirmed or highly suspected primary hyperaldosteronism treated by unilateral adrenalectomy were retrospectively included in this study. The most frequent clinical signs were lethargy (nā=ā20; 69%) and… read more here.
Keywords: hyperaldosteronism; unilateral adrenalectomy; primary hyperaldosteronism; adrenalectomy ... See more keywords
SAT-072 Recurrent Hypokalemic Paralysis: A Case Of Delayed Diagnosis Of Primary Hyperaldosteronism
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-072
Abstract: Abstract Introduction: Acute hypokalemic paralysis is a relatively rare, potentially life threatening but treatable cause of acute myopathy. Rapid diagnosis with appropriate treatment is critical. Herein, we present a case of hypokalemic paralysis due to… read more here.
Keywords: paralysis; hypokalemic paralysis; case; primary hyperaldosteronism ... See more keywords
ASO Author Reflections: Predicting Postoperative Resolution of Hypertension in Primary Hyperaldosteronism
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DOI: 10.1245/s10434-021-09762-w
Abstract: While hypokalemia routinely normalizes after unilateral adrenalectomy for primary hyperaldosteronism (PA), only one-third of patients will achieve postoperative normotension, and our ability to preoperatively identify those who will become normotensive remains both a priority and… read more here.
Keywords: resolution; hyperaldosteronism; author reflections; primary hyperaldosteronism ... See more keywords
Topical Diagnosis and Determination of the Primary Hyperaldosteronism Variant
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DOI: 10.25122/jml-2019-0072
Abstract: Laboratory diagnosis of primary hyperaldosteronism is based on determining blood levels of aldosterone, renin on request, potassium, and sodium. The results of these studies are significantly influenced by drugs, preparation for the study and blood… read more here.
Keywords: diagnosis; primary hyperaldosteronism; determination primary; topical diagnosis ... See more keywords
A Novel Somatic Mutation of CACNA1H p.V1937M in Unilateral Primary Hyperaldosteronism
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DOI: 10.3389/fendo.2022.816476
Abstract: Background Somatic mutations for excess aldosterone production have been frequently identified as important roles in the pathogenesis of unilateral primary hyperaldosteronism (uPA). Although CACNA1H mutation represents a minor etiology in primary aldosteronism, it plays a… read more here.
Keywords: cacna1h v1937m; unilateral primary; primary hyperaldosteronism; novel somatic ... See more keywords
Primary Hyperaldosteronism and Renal Medullary Nephrocalcinosis: A Controversial Association
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DOI: 10.5001/omj.2021.32
Abstract: Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5ā10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma. The three commonest… read more here.
Keywords: nephrocalcinosis; hyperaldosteronism renal; primary hyperaldosteronism; renal medullary ... See more keywords