Activated PI3K-delta syndrome in an Egyptian pediatric cohort with primary immune deficiency.
Sign Up to like & getrecommendations! Published in 2020 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2019.12.006
Abstract: BACKGROUND Activated Phospho-Inositide 3 (PI3) Kinases Delta syndrome (APDS) can underlie primary immune deficiency. The prevalence and phenotypic characterization of these patients are not well described in Egypt. OBJECTIVES To describe patients with APDS in… read more here.
Keywords: delta syndrome; cohort; primary immune; immune deficiency ... See more keywords
Indirubin regulates MPL and TNF expression in peripheral blood mononuclear cells from patients with primary immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2019.04.002
Abstract: Indirubin, a traditional Chinese medicine, is currently used to treat certain autoimmune diseases such as primary immune thrombocytopenia (ITP) in clinics. However, the effects of indirubin on expression of related genes in peripheral blood mononuclear… read more here.
Keywords: tnf expression; blood mononuclear; primary immune; expression ... See more keywords
Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease.
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2017.10.016
Abstract: BACKGROUND More than half of all primary immune deficiency diseases (PIDD) affect antibody production and are well known as causes of recurrent sinusitis and lung infections. Chronic and recurrent infections of the upper and/or lower… read more here.
Keywords: deficiency diseases; disease; diseases unrecognized; primary immune ... See more keywords
Tumor Necrosis Factor-α Blockade Corrects Monocyte/Macrophage Imbalance in Primary Immune Thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0040-1722186
Abstract: Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder. Monocytes and macrophages are the major cells involved in autoantibody-mediated platelet clearance in ITP. In the present study, we found increased percentages of peripheral blood… read more here.
Keywords: blockade; primary immune; immune thrombocytopenia; tumor necrosis ... See more keywords
The effect of anti-thyroid antibodies positivity on children with primary immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2017.1400136
Abstract: ABSTRACT Primary immune thrombocytopenia (ITP) is the most common cause of acquired thrombocytopenia in children. Anti-thyroid antibodies (aTA) have previously been found to be present in various autoimmune diseases. Our aim was to study the… read more here.
Keywords: anti thyroid; group; primary immune; children primary ... See more keywords
Fibrinogen levels are associated with bleeding in patients with primary immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2019 at "Platelets"
DOI: 10.1080/09537104.2019.1678115
Abstract: Abstract Bleeding is the most common clinical symptom and the leading cause of death in patients with primary immune thrombocytopenia (ITP). Our research intends to verify the role of fibrinogen levels as independent determinants of… read more here.
Keywords: bleeding patients; fibrinogen; fibrinogen levels; primary immune ... See more keywords
Immune dysregulation in primary immune thrombocytopenia patients
Sign Up to like & getrecommendations! Published in 2018 at "Hematology"
DOI: 10.1080/10245332.2018.1435021
Abstract: ABSTRACT Objectives: To explore the immunological abnormalities in patients with primary immune thrombocytopenia (ITP), and analyze its relationship with treatment. Methods: Proportion of different immune cell subsets were detected in the peripheral blood of 124… read more here.
Keywords: treatment; group; itp patients; primary immune ... See more keywords
Decreased function of Fas and variations of the perforin gene in adult patients with primary immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14248
Abstract: A defective switching off of the immune response is involved in several autoimmune diseases. This switching off involves Fas‐mediated apoptosis, perforin‐mediated fratricide of activated lymphocytes, and the suppressive activity of regulatory T (Treg) cells. These… read more here.
Keywords: thrombocytopenia; itp patients; primary immune; immune thrombocytopenia ... See more keywords
Proteomic analysis and microRNA expression profiling of plasma‐derived exosomes in primary immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17720
Abstract: Exosomes are released into extracellular fluids and have emerged as vital biological mediators in autoimmune diseases. Plasma‐derived exosomes have been reported to take part in the pathogenesis of primary immune thrombocytopenia (ITP), but the protein… read more here.
Keywords: mir; primary immune; immune thrombocytopenia; proteomic analysis ... See more keywords
HDAC3 single‐nucleotide polymorphism rs2530223 is associated with increased susceptibility and severity of primary immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13857
Abstract: Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by a low platelet count and increased risk of bleeding. We previously reported that low‐dose chidamide, a histone deacetylase (HDAC) inhibitor, restores immune tolerance in… read more here.
Keywords: primary immune; immune thrombocytopenia; nucleotide polymorphism; single nucleotide ... See more keywords
Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16469
Abstract: Abstract Background Current reports about the use of splenectomy for the management of immune‐mediated hemolytic anemia (IMHA) or immune‐mediated thrombocytopenia (ITP) or both in dogs are limited. Objectives To retrospectively describe the use of splenectomy… read more here.
Keywords: splenectomy part; primary immune; management; immune mediated ... See more keywords