YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202412515
Abstract: Primary immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by decreased platelet count and increased risk of hemorrhage, in which macrophages play an important role in the pathogenesis. This study aims to explore the… read more here.
Keywords: reticulum stress; thrombocytopenia; primary immune; immune thrombocytopenia ... See more keywords
Plasma Exosomes Derived from Patients with Primary Immune Thrombocytopenia Attenuate TBX21+ Regulatory T Cell-Mediated Immune Suppression via MiR-363-3p
Sign Up to like & getrecommendations! Published in 2025 at "Inflammation"
DOI: 10.1007/s10753-025-02275-8
Abstract: Primary Immune Thrombocytopenia (ITP) is characterized by reduced immunosuppressive function of regulatory T cells (Tregs), contributing to immune imbalance and decreased platelet counts. However, the mechanisms behind this reduced efficacy of Tregs remain unclear. Our… read more here.
Keywords: spi1 tbx21; primary immune; immune thrombocytopenia; cell ... See more keywords
Activated PI3K-delta syndrome in an Egyptian pediatric cohort with primary immune deficiency.
Sign Up to like & getrecommendations! Published in 2020 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2019.12.006
Abstract: BACKGROUND Activated Phospho-Inositide 3 (PI3) Kinases Delta syndrome (APDS) can underlie primary immune deficiency. The prevalence and phenotypic characterization of these patients are not well described in Egypt. OBJECTIVES To describe patients with APDS in… read more here.
Keywords: delta syndrome; cohort; primary immune; immune deficiency ... See more keywords
Indirubin regulates MPL and TNF expression in peripheral blood mononuclear cells from patients with primary immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2019.04.002
Abstract: Indirubin, a traditional Chinese medicine, is currently used to treat certain autoimmune diseases such as primary immune thrombocytopenia (ITP) in clinics. However, the effects of indirubin on expression of related genes in peripheral blood mononuclear… read more here.
Keywords: tnf expression; blood mononuclear; primary immune; expression ... See more keywords
Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease.
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DOI: 10.1016/j.rmed.2017.10.016
Abstract: BACKGROUND More than half of all primary immune deficiency diseases (PIDD) affect antibody production and are well known as causes of recurrent sinusitis and lung infections. Chronic and recurrent infections of the upper and/or lower… read more here.
Keywords: deficiency diseases; disease; diseases unrecognized; primary immune ... See more keywords
Tumor Necrosis Factor-α Blockade Corrects Monocyte/Macrophage Imbalance in Primary Immune Thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0040-1722186
Abstract: Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder. Monocytes and macrophages are the major cells involved in autoantibody-mediated platelet clearance in ITP. In the present study, we found increased percentages of peripheral blood… read more here.
Keywords: blockade; primary immune; immune thrombocytopenia; tumor necrosis ... See more keywords
The effect of anti-thyroid antibodies positivity on children with primary immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2017.1400136
Abstract: ABSTRACT Primary immune thrombocytopenia (ITP) is the most common cause of acquired thrombocytopenia in children. Anti-thyroid antibodies (aTA) have previously been found to be present in various autoimmune diseases. Our aim was to study the… read more here.
Keywords: anti thyroid; group; primary immune; children primary ... See more keywords
Fibrinogen levels are associated with bleeding in patients with primary immune thrombocytopenia
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DOI: 10.1080/09537104.2019.1678115
Abstract: Abstract Bleeding is the most common clinical symptom and the leading cause of death in patients with primary immune thrombocytopenia (ITP). Our research intends to verify the role of fibrinogen levels as independent determinants of… read more here.
Keywords: bleeding patients; fibrinogen; fibrinogen levels; primary immune ... See more keywords
Immune dysregulation in primary immune thrombocytopenia patients
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DOI: 10.1080/10245332.2018.1435021
Abstract: ABSTRACT Objectives: To explore the immunological abnormalities in patients with primary immune thrombocytopenia (ITP), and analyze its relationship with treatment. Methods: Proportion of different immune cell subsets were detected in the peripheral blood of 124… read more here.
Keywords: treatment; group; itp patients; primary immune ... See more keywords
Cutaneous manifestations of primary immune deficiencies
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DOI: 10.1080/15569527.2025.2511721
Abstract: Abstract Purpose Primary immune deficiencies (PIDs) can present with a wide range of clinical findings. This review aims to evaluate PIDs in which cutaneous findings are common. Materials and methods English literature regarding cutaneous manifestations… read more here.
Keywords: cutaneous manifestations; manifestations primary; primary immune; immune deficiencies ... See more keywords
Malignancies and Lymphoproliferations in Children With Primary Immune Deficiency—A Single-center Experience
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DOI: 10.1097/mph.0000000000002817
Abstract: Primary immune deficiencies (PIDs) are rare genetic disorders characterized by impaired immune function, leading to frequent infections and immune dysregulation. Studies have shown that individuals with PID are at an increased risk of developing malignancies… read more here.
Keywords: lymphoproliferations children; primary immune; single center; malignancy ... See more keywords