Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2409636121
Abstract: Significance The synaptic sensitive factor attachment protein receptor (SNARE) complex and synaptotagmin-1 (Syt1) are required for fast neurotransmitter release. The functions of Syt1 in preparing synaptic vesicles for fusion and executing the triggering step have… read more here.
Keywords: primary interface; snare complex; snare; synaptotagmin ... See more keywords
Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.891041
Abstract: The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1,… read more here.
Keywords: stapled peptides; primary interface; ca2; hydrocarbon stapled ... See more keywords