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   Articles with "primary lateral" as a keyword



Primary Lateral Sclerosis Natural History Study: Primary Lateral Sclerosis Functional Rating Scale and Other Outcomes Assessment.

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recommendations! Published in 2025 at "Annals of neurology"

DOI: 10.1002/ana.78056

Abstract: OBJECTIVE The primary lateral sclerosis (PLS) consensus diagnostic criteria and functional rating scale (PLSFRS) were recently established to facilitate and optimize future PLS clinical trials. We examined the trajectory of the PLSFRS and other functional… read more here.

Keywords: history; pls; primary lateral; study ... See more keywords
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Extra-motor cerebral changes and manifestations in primary lateral sclerosis.

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recommendations! Published in 2021 at "Brain imaging and behavior"

DOI: 10.1007/s11682-020-00421-4

Abstract: Primary lateral sclerosis (PLS) is classically considered a 'pure' upper motor neuron disorder. Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of PLS, but extra-motor cerebral changes are poorly characterized. In… read more here.

Keywords: primary lateral; pls; motor cerebral; motor ... See more keywords

Utility of intrathecal baclofen pump in primary lateral sclerosis

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recommendations! Published in 2021 at "Journal of the Neurological Sciences"

DOI: 10.1016/j.jns.2020.117227

Abstract: Primary lateral sclerosis is a disorder categorized by insidious onset of progressive upper motor neuron dysfunction without lower motor neuron involvement. PLS often presents with gradual-onset, progressive lower extremity stiffness and pain due to muscle… read more here.

Keywords: primary lateral; pls; intrathecal baclofen; spasticity ... See more keywords

Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-85786-6

Abstract: Primary lateral sclerosis (PLS) is a motor neuron disease (MND) which mainly affects upper motor neurons. Within the MND spectrum, PLS is much more slowly progressive than amyotrophic laterals sclerosis (ALS). `Classical` ALS is characterized… read more here.

Keywords: primary lateral; automatic segmentation; lateral sclerosis; volume ... See more keywords

Macroglossia in primary lateral sclerosis: a case report

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recommendations! Published in 2019 at "International Journal of Neuroscience"

DOI: 10.1080/00207454.2019.1645141

Abstract: Abstract Purpose/Aim: Macroglossia is a rare condition, especially in patients with motor neuron disease. In this case report, we describe a patient with macroglossia in the early stages of motor neuron disease. Case report: A… read more here.

Keywords: primary lateral; motor neuron; report; neuron disease ... See more keywords

Cerebellar degeneration in primary lateral sclerosis: an under-recognized facet of PLS

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recommendations! Published in 2022 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"

DOI: 10.1080/21678421.2021.2023188

Abstract: Abstract While primary lateral sclerosis (PLS) has traditionally been regarded as a pure upper motor neuron disorder, recent clinical, neuroimaging and postmortem studies have confirmed significant extra-motor involvement. Sporadic reports have indicated that in addition… read more here.

Keywords: degeneration; sclerosis; primary lateral; lateral sclerosis ... See more keywords

Does limited EMG denervation in early primary lateral sclerosis predict amyotrophic lateral sclerosis?

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recommendations! Published in 2022 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"

DOI: 10.1080/21678421.2022.2039714

Abstract: Abstract Objective: We assessed whether a cohort of patients with primary lateral sclerosis (PLS) and limited electromyography (EMG) motor unit denervation changes evolve into amyotrophic lateral sclerosis (ALS) with prolonged follow-up. Methods: We initially ascertained… read more here.

Keywords: emg denervation; sclerosis; primary lateral; lateral sclerosis ... See more keywords

Cortico-muscular coherence in primary lateral sclerosis reveals abnormal cortical engagement during motor function beyond primary motor areas.

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recommendations! Published in 2023 at "Cerebral cortex"

DOI: 10.1093/cercor/bhad152

Abstract: Primary lateral sclerosis (PLS) is a slowly progressing disorder, which is characterized primarily by the degeneration of upper motor neurons (UMNs) in the primary motor area (M1). It is not yet clear how the function… read more here.

Keywords: primary lateral; cortico muscular; lateral sclerosis; motor ... See more keywords

Familial clustering of primary lateral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum.

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recommendations! Published in 2021 at "European journal of neurology"

DOI: 10.1111/ene.15146

Abstract: In their article, Corcia et al. describe a series of 9 patients suffering from primary lateral sclerosis (PLS) coming from different family clusters, in which every individual had a first- or second-degree relative affected by… read more here.

Keywords: primary lateral; sclerosis; continuum; amyotrophic lateral ... See more keywords

Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis

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recommendations! Published in 2023 at "European Journal of Neurology"

DOI: 10.1111/ene.15725

Abstract: Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms are typically exclusively linked to primary motor cortex degeneration and the contribution of pre‐motor, supplementary motor, cortico‐medullary and… read more here.

Keywords: primary lateral; motor; lateral sclerosis; motor neuron ... See more keywords

Atypical features including acquired oculomotor apraxia in C9orf72-associated familial primary lateral sclerosis.

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recommendations! Published in 2025 at "Journal of neuromuscular diseases"

DOI: 10.1177/22143602251380427

Abstract: BACKGROUND The phenotypic variability of C9orf72-associated disease is broadening, including atypical and non-motor presentations. C9orf72-associated neurodegeneration has only rarely been associated with primary lateral sclerosis (PLS), and even more rarely with ocular motor apraxia. OBJECTIVES… read more here.

Keywords: c9orf72; apraxia; pls; c9orf72 associated ... See more keywords