Extra-motor cerebral changes and manifestations in primary lateral sclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Brain imaging and behavior"
DOI: 10.1007/s11682-020-00421-4
Abstract: Primary lateral sclerosis (PLS) is classically considered a 'pure' upper motor neuron disorder. Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of PLS, but extra-motor cerebral changes are poorly characterized. In… read more here.
Keywords: primary lateral; pls; motor cerebral; motor ... See more keywords
Utility of intrathecal baclofen pump in primary lateral sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2020.117227
Abstract: Primary lateral sclerosis is a disorder categorized by insidious onset of progressive upper motor neuron dysfunction without lower motor neuron involvement. PLS often presents with gradual-onset, progressive lower extremity stiffness and pain due to muscle… read more here.
Keywords: primary lateral; pls; intrathecal baclofen; spasticity ... See more keywords
Macroglossia in primary lateral sclerosis: a case report
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2019.1645141
Abstract: Abstract Purpose/Aim: Macroglossia is a rare condition, especially in patients with motor neuron disease. In this case report, we describe a patient with macroglossia in the early stages of motor neuron disease. Case report: A… read more here.
Keywords: primary lateral; motor neuron; report; neuron disease ... See more keywords
Cerebellar degeneration in primary lateral sclerosis: an under-recognized facet of PLS
Sign Up to like & getrecommendations! Published in 2022 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2021.2023188
Abstract: Abstract While primary lateral sclerosis (PLS) has traditionally been regarded as a pure upper motor neuron disorder, recent clinical, neuroimaging and postmortem studies have confirmed significant extra-motor involvement. Sporadic reports have indicated that in addition… read more here.
Keywords: degeneration; sclerosis; primary lateral; lateral sclerosis ... See more keywords
Does limited EMG denervation in early primary lateral sclerosis predict amyotrophic lateral sclerosis?
Sign Up to like & getrecommendations! Published in 2022 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2022.2039714
Abstract: Abstract Objective: We assessed whether a cohort of patients with primary lateral sclerosis (PLS) and limited electromyography (EMG) motor unit denervation changes evolve into amyotrophic lateral sclerosis (ALS) with prolonged follow-up. Methods: We initially ascertained… read more here.
Keywords: emg denervation; sclerosis; primary lateral; lateral sclerosis ... See more keywords
Cortico-muscular coherence in primary lateral sclerosis reveals abnormal cortical engagement during motor function beyond primary motor areas.
Sign Up to like & getrecommendations! Published in 2023 at "Cerebral cortex"
DOI: 10.1093/cercor/bhad152
Abstract: Primary lateral sclerosis (PLS) is a slowly progressing disorder, which is characterized primarily by the degeneration of upper motor neurons (UMNs) in the primary motor area (M1). It is not yet clear how the function… read more here.
Keywords: primary lateral; cortico muscular; lateral sclerosis; motor ... See more keywords
Familial clustering of primary lateral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of neurology"
DOI: 10.1111/ene.15146
Abstract: In their article, Corcia et al. describe a series of 9 patients suffering from primary lateral sclerosis (PLS) coming from different family clusters, in which every individual had a first- or second-degree relative affected by… read more here.
Keywords: primary lateral; sclerosis; continuum; amyotrophic lateral ... See more keywords
Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Neurology"
DOI: 10.1111/ene.15725
Abstract: Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms are typically exclusively linked to primary motor cortex degeneration and the contribution of pre‐motor, supplementary motor, cortico‐medullary and… read more here.
Keywords: primary lateral; motor; lateral sclerosis; motor neuron ... See more keywords
Primary Lateral Sclerosis Presenting With Focal Onset Spreading Through Contiguous Neuroanatomic Regions
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DOI: 10.1212/wnl.0000000000200011
Abstract: A 66-year-old woman complained of a 3-year history of left ankle focal spasticity. Brain MRI revealed subcortical white matter hyperintensity in the medial region of the right precentral gyrus. Subsequently, motor impairment spread proximally, to… read more here.
Keywords: focal onset; primary lateral; lateral sclerosis; sclerosis presenting ... See more keywords
Low-Dose Intrathecal Ziconotide for Spasticity From Primary Lateral Sclerosis: A Case Report.
Sign Up to like & getrecommendations! Published in 2019 at "A&A Practice"
DOI: 10.1213/xaa.0000000000000978
Abstract: Spasticity can be very debilitating and painful. We present a case of severe spasticity from primary lateral sclerosis refractory to intrathecal baclofen in doses up to 1100 μg/d. Baclofen was weaned down and switched to… read more here.
Keywords: intrathecal ziconotide; primary lateral; case; spasticity ... See more keywords