The impacts of C1q/TNF-related protein-15 and adiponectin on Interleukin-6 and tumor necrosis factor-α in primary macrophages of patients with coronary artery diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155470
Abstract: Atherosclerosis is a progressive inflammatory disease characterized by the accumulation of lipids in the arterial wall. Inflammation plays a key role in the pathogenesis of atherosclerosis and some previous studies have shown the role of… read more here.
Keywords: anti inflammatory; patients coronary; adiponectin ctrp15; coronary artery ... See more keywords
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13580-0
Abstract: ADAR1-dependent A-to-I editing has recently been recognized as a key process for marking dsRNA as self, therefore, preventing innate immune activation and affecting the development and resolution of immune-mediated diseases and infections. Here, we have… read more here.
Keywords: adar1; adar1 knockdown; immune activation; innate immune ... See more keywords
A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121400119
Abstract: Significance Iron misdistribution underlies various diseases, ranging from anemia to neurodegeneration, but approaches to addressing this general problem are lacking. We recently reported that a small molecule natural product, hinokitiol, is capable of restoring hemoglobinization… read more here.
Keywords: small molecule; iron; ferroportin deficient; deficient mice ... See more keywords
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.723683
Abstract: Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria. Here, we explored how MFN2 influences mitochondrial functions and inflammatory responses towards zymosan… read more here.
Keywords: mfn2 deficiency; human primary; inflammatory effects; deficiency ... See more keywords
Zirconia-Toughened Alumina Ceramic Wear Particles Do Not Elicit Inflammatory Responses in Human Macrophages
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076482
Abstract: Ten percent of patients undergoing total hip arthroplasty (THA) require revision surgery. One of the reasons for THA are wear particles released from the implants that can activate the immune defense and cause osteolysis and… read more here.
Keywords: zirconia toughened; thp macrophages; toughened alumina; primary macrophages ... See more keywords