Multiple primary melanomas: Is there a correlation between dermoscopic features and germline mutations?
Sign Up to like & getrecommendations! Published in 2023 at "Australasian Journal of Dermatology"
DOI: 10.1111/ajd.14007
Abstract: % of MPMs. 8 Colombino et al. reported a higher concordance rate (66.7%) but limited to only 12 patients. In our study, the concordance rate was 55.7%, consistently with previous studies. 9 This was higher… read more here.
Keywords: primary melanomas; correlation dermoscopic; dermoscopic; multiple primary ... See more keywords
Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-4189
Abstract: Purpose: Cutaneous and unknown primary melanomas frequently harbor alterations that activate the MAPK pathway. Whether MAPK driver detection beyond BRAF V600 is clinically relevant in the checkpoint inhibitor era is unknown. Experimental Design: Patients with… read more here.
Keywords: unknown primary; mapk pathway; driver; primary melanomas ... See more keywords
Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5984-7
Abstract: IntroductionMultiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germline mutation have been describe… read more here.
Keywords: analysis; somatic mutations; primary melanomas; germline somatic ... See more keywords
Therapeutic implications of a novel driver classification system for cutaneous and unknown primary melanomas.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.9539
Abstract: 9539 Background: Cutaneous and “unknown primary” melanomas frequently harbor alterations that activate the Mitogen Activated Protein Kinase (MAPK) pathway, and are often classified as BRAF, NRAS, NF1 mutant, or “triple wild type.” Multigene sequencing may… read more here.
Keywords: unknown primary; melanoma; driver; primary melanomas ... See more keywords
Detailed spatial immunophenotyping of primary melanomas reveals immune cell subpopulations associated with patient outcome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.979993
Abstract: While the tumor immune microenvironment (TIME) of metastatic melanoma has been well characterized, the primary melanoma TIME is comparatively poorly understood. Additionally, although the association of tumor-infiltrating lymphocytes with primary melanoma patient outcome has been… read more here.
Keywords: primary melanomas; primary melanoma; cell; patient outcome ... See more keywords