In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.01.026
Abstract: Phthalic acid esters have been widely used to improve the plasticity of PVC medical devices. They carry a high exposure risk for both humans and the environment in clinical situations. Our study focuses on the… read more here.
Keywords: line; cytotoxic; primary metabolites; cytotoxicity ... See more keywords
Pharmacokinetics of LBPT and its primary metabolites, as well as tolerability in the first‐in‐human study
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.12.038
Abstract: Background: LBPT is a novel platelet‐activating factor (PAF) receptor antagonist that is developed for the treatment of rheumatoid arthritis. The purpose of this first‐in‐human study was to evaluate the tolerability and safety of LBPT, to… read more here.
Keywords: primary metabolites; pharmacokinetics lbpt; study; human study ... See more keywords
Diurnal changes in CN metabolism and response of rice seedlings to UV-B radiation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2018.02.007
Abstract: Plants regulate a number of primary metabolites, including carbohydrates, organic acids, and amino acids, in response to UV-B radiation. Therefore, it is essential to understand the time-dependent response of rice plants to UV-B stress. This… read more here.
Keywords: response; primary metabolites; rice seedlings; response rice ... See more keywords
On-line clean-up and LC-MS analysis of primary metabolites in cell culture supernatants
Sign Up to like & getrecommendations! Published in 2017 at "Analytical Methods"
DOI: 10.1039/c7ay02034a
Abstract: Current approaches to modern metabolic profiling of biotechnological samples are facing several challenges, e.g. the wide concentration ranges and the complexity of the matrix. While the information on concentration levels of extracellular metabolites is much… read more here.
Keywords: analysis; primary metabolites; matrix; line clean ... See more keywords
Systematic analysis of in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Biochemistry"
DOI: 10.1101/2022.09.28.509873
Abstract: Flow-injection mass spectrometry (FI-MS) enables metabolomics studies with a very high sample-throughput. However, FI-MS is prone to in-source modifications of analytes because samples are directly injected into the electrospray ionization source of a mass spectrometer… read more here.
Keywords: source modifications; mass spectrometry; source; flow injection ... See more keywords
Qualitative and Quantitative Evaluation of Chemical Constituents from Shuanghuanglian Injection Using Nuclear Magnetic Resonance Spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2022/7763207
Abstract: By employing nuclear magnetic resonance (NMR), we implemented a chemical research on Shuanghuanglian injection (SHLI) and identified 17 components, including eight primary metabolites and nine secondary metabolites. Guided by the approach of network pharmacology, the… read more here.
Keywords: nuclear magnetic; primary metabolites; spectroscopy; magnetic resonance ... See more keywords
Simultaneous untargeted and targeted metabolomics profiling of underivatized primary metabolites in sulfur-deficient barley by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Plant Methods"
DOI: 10.1186/s13007-018-0329-0
Abstract: BackgroundMetabolomics based on mass spectrometry analysis are increasingly applied in diverse scientific domains, notably agronomy and plant biology, in order to understand plants’ behaviors under different stress conditions. In fact, these stress conditions are able… read more here.
Keywords: simultaneous untargeted; barley; mass spectrometry; primary metabolites ... See more keywords
Primary Metabolite Chromatographic Profiling as a Tool for Chemotaxonomic Classification of Seeds from Berry Fruits
Sign Up to like & getrecommendations! Published in 2022 at "Food Technology and Biotechnology"
DOI: 10.17113/ftb.60.03.22.7505
Abstract: SUMMARY Research background Considering the importance of consumption of berry fruits with proven health-beneficial properties and difficulties in quality control of products of specific botanical and geographic origin, a fingerprint method was developed, based on… read more here.
Keywords: berry fruits; primary metabolite; classification; methodology ... See more keywords
Isolation and Identification of some Primary Metabolites, Micro- and Macroelements of Aesculus hippocastanum L. Seeds
Sign Up to like & getrecommendations! Published in 2017 at "Phytopathology"
DOI: 10.25258/ijpapr.v9i1.8049
Abstract: The qualitative composition and quantitative content of amino acids were studied by PC and HPLC methods. 15 free amino acids were identified in the endosperm and skin of A. hippocastanum. 16 bound amino acids were… read more here.
Keywords: hippocastanum; seed; acids identified; amino acids ... See more keywords
Root Exudation of Primary Metabolites: Mechanisms and Their Roles in Plant Responses to Environmental Stimuli
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00157
Abstract: Root exudation is an important process determining plant interactions with the soil environment. Many studies have linked this process to soil nutrient mobilization. Yet, it remains unresolved how exudation is controlled and how exactly and… read more here.
Keywords: exudation; exudation primary; plant; primary metabolites ... See more keywords
Secondary and primary metabolites reveal putative resistance-associated biomarkers against Erysiphe necator in resistant grapevine genotypes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1112157
Abstract: Numerous fungicide applications are required to control Erysiphe necator, the causative agent of powdery mildew. This increased demand for cultivars with strong and long-lasting field resistance to diseases and pests. In comparison to the susceptible… read more here.
Keywords: necator; necator resistant; primary metabolites; resistance ... See more keywords