Activation of EP2 receptor suppresses poly(I: C) and LPS‐mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for MAPKs
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23276
Abstract: Brain inflammation is a critical factor involved in neurodegeneration. Recently, the prostaglandin E2 (PGE2) downstream members were suggested to modulate neuroinflammatory responses accompanying neurodegenerative diseases. In this study, we investigated the protective effects of prostaglandin… read more here.
Keywords: ep2 receptor; primary microglia; organotypic hippocampal; hippocampal slice ... See more keywords
Esculentoside A exerts anti‐inflammatory activity in microglial cells
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.08.014
Abstract: Abstract Esculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. This study was designed to evaluate the pharmacological effects of EsA on lipopolysaccharide (LPS)‐stimulated BV2 microglia and primary microglia cells. Our… read more here.
Keywords: anti inflammatory; primary microglia; bgr; esculentoside exerts ... See more keywords
Oxymatrine exhibits anti-neuroinflammatory effects on Aβ1-42-induced primary microglia cells by inhibiting NF-κB and MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105686
Abstract: Oxymatrine (OMT), isolated from Sophora flavescens or Sophora alopecuroides, possesses various pharmacological and biological activities, including anti-inflammatory, anti-oxidant, and anti-diabetic properties. Microglia cells, the resident immune cells in the central nervous system (CNS), play a… read more here.
Keywords: primary microglia; exhibits anti; microglia cells; neuroinflammatory effects ... See more keywords
Age and sex differences in primary microglia culture: A comparative study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2021.109359
Abstract: BACKGROUND Microglia play a central role in neuroinflammation in various CNS diseases.Neonatal microglial culture has been extensively used to in vitro study microglial activation; however, as many neuroinflammatory diseases occur in the elderly, the neonatal… read more here.
Keywords: primary microglia; age; sex differences; study ... See more keywords
Differential response to lead toxicity in rat primary microglia and astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.11.010
Abstract: ABSTRACT Lead (Pb) is one of the most widely studied occupational and environmental toxins. Chronic exposure to Pb affects neural function in the central nervous system (CNS). Glial cells in the CNS, such as microglia… read more here.
Keywords: primary microglia; microglia astrocytes; response; oxidative stress ... See more keywords
Primary microglia maintain their capacity to function despite internalisation and intracellular loading with carbon nanotubes.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale horizons"
DOI: 10.1039/c7nh00055c
Abstract: Biomedical applications of functionalised carbon nanotubes (f-CNTs) for imaging as well as drug or gene delivery in the brain have recently gained interest. Several studies have demonstrated the potential of f-CNTs to offer treatment options… read more here.
Keywords: primary microglia; maintain capacity; carbon nanotubes; microglia maintain ... See more keywords
Two-Photon Polymerization of 2.5D and 3D Microstructures Fostering a Ramified Resting Phenotype in Primary Microglia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.926642
Abstract: Microglia are the resident macrophages of the central nervous system and contribute to maintaining brain’s homeostasis. Current 2D “petri-dish” in vitro cell culturing platforms employed for microglia, are unrepresentative of the softness or topography of… read more here.
Keywords: two photon; phenotype; polymerization microstructures; photon polymerization ... See more keywords
Mapping the Plasticity of Morphology, Molecular Properties and Function in Mouse Primary Microglia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.811061
Abstract: Microglia exert diverse functions by responding in diverse ways to different stimuli, yet little is known about the plasticity of various phenotypes that microglia display. We used interferon (IFN)-γ, interleukin (IL)-4 and IL-10 to induce… read more here.
Keywords: mouse primary; phenotype; plasticity; primary microglia ... See more keywords
Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179829
Abstract: The sex and APOE4 genotype are significant risk factors for Alzheimer’s disease (AD); however, the mechanism(s) responsible for this interaction are still a matter of debate. Here, we assess the responses of mixed-sex and sex-specific… read more here.
Keywords: pmg; genotype; sex; sex specific ... See more keywords