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   Articles with "primary myelofibrosis" as a keyword



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Early detection of pulmonary hypertension in primary myelofibrosis: The role of echocardiography, cardiopulmonary exercise testing, and biomarkers

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recommendations! Published in 2017 at "American Journal of Hematology"

DOI: 10.1002/ajh.24656

Abstract: of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2016 [Epub ahead of print]. [5] Ostronoff F, Othus M, Lazenby M, et al. Prognostic significance of NPM1 mutations in the absence… read more here.

Keywords: pulmonary hypertension; myelofibrosis role; early detection; primary myelofibrosis ... See more keywords
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Elevated expression of the EZH2 gene in CALR-mutated patients with primary myelofibrosis

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recommendations! Published in 2018 at "Annals of Hematology"

DOI: 10.1007/s00277-018-3287-8

Abstract: Primary myelofibrosis (PMF) is one of the BCR/ABL-negative myeloproliferative neoplasms (MPNs), characterized by the diffuse fibrous hyperproliferation, bone marrow osteosclerosis, extramedullary hematopoiesis, and marked splenomegaly. The patients with PMF have an insidious onset, a long… read more here.

Keywords: mutated patients; primary myelofibrosis; calr mutated; expression ezh2 ... See more keywords
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Prognostic value of ASXL1 mutations in patients with primary myelofibrosis and its relationship with clinical features: a meta-analysis

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recommendations! Published in 2021 at "Annals of Hematology"

DOI: 10.1007/s00277-020-04387-7

Abstract: Additional sex combs like 1 (ASXL1) mutations are one of the most common molecular biological abnormalities in patients with primary myelofibrosis (PMF), and the effect of these mutations on prognosis remains controversial. Hence, we conducted… read more here.

Keywords: primary myelofibrosis; prognostic value; asxl1 mutations; patients primary ... See more keywords
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Post-ET and Post-PV Myelofibrosis: Updates on a Distinct Prognosis from Primary Myelofibrosis

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recommendations! Published in 2018 at "Current Hematologic Malignancy Reports"

DOI: 10.1007/s11899-018-0453-y

Abstract: Purpose of ReviewThe purpose of this review is to help doctors in the management of patients with post-polycythemia (PPV) and post-essential thrombocythemia (PET) myelofibrosis (MF) facing diagnostic criteria, prognostication, and treatment possibilities.Recent FindingsDiagnostic criteria of… read more here.

Keywords: primary myelofibrosis; post myelofibrosis; myelofibrosis; post post ... See more keywords
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Herpes simplex vegetans in a patient with primary myelofibrosis

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recommendations! Published in 2019 at "Infection"

DOI: 10.1007/s15010-019-01329-y

Abstract: A 45-year-old woman was admitted to our department with painless ulcerated plaque at the left labial angle. The lesion had developed several months ago and was slowly enlarging. Upon admission, she had already received several… read more here.

Keywords: simplex vegetans; vegetans patient; primary myelofibrosis; patient primary ... See more keywords
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Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

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recommendations! Published in 2018 at "Hematology, Transfusion and Cell Therapy"

DOI: 10.1016/j.htct.2017.12.003

Abstract: Background Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods This study examined the plasma cytokine profiles… read more here.

Keywords: neoplasms disorders; philadelphia negative; primary myelofibrosis; negative myeloproliferative ... See more keywords
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JAK2-mutated Langerhans cell histiocytosis associated with primary myelofibrosis treated with ruxolitinib.

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recommendations! Published in 2018 at "Human pathology"

DOI: 10.1016/j.humpath.2017.10.017

Abstract: The pathogenesis and cellular origin of Langerhans cell histiocytosis (LCH) are debated. Recently, mutations on MAPK and PI3K pathways have been linked to disrupted cell proliferation in LCH. Janus Kinase 2 (JAK2) mutations play the… read more here.

Keywords: langerhans cell; cell histiocytosis; primary myelofibrosis; jak2 ... See more keywords
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Unusual presentation of primary myelofibrosis with spontaneous bleeding after laparoscopic adrenalectomy: A case report

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recommendations! Published in 2020 at "International Journal of Surgery Case Reports"

DOI: 10.1016/j.ijscr.2020.09.100

Abstract: Highlights • Uncommon presentation.• Primary myelofibrosis.• Laparoscopic adrenalectomy.• Spontaneous bleeding. read more here.

Keywords: primary myelofibrosis; presentation primary; spontaneous bleeding; laparoscopic adrenalectomy ... See more keywords
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Marked elevation of serum lactate dehydrogenase in primary myelofibrosis: clinical and prognostic correlates

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recommendations! Published in 2017 at "Blood Cancer Journal"

DOI: 10.1038/s41408-017-0024-9

Abstract: Primary myelofibrosis (PMF) is a clonal stem cell-derived myeloproliferative neoplasm (MPN), characterized by dysregulated proliferation of megakaryocytes, myeloid and erythroid cells, extramedullary hematopoiesis, and reactive changes in the bone marrow, including reticulin deposition, osteosclerosis, and… read more here.

Keywords: primary myelofibrosis; pmf; pre pmf; serum ... See more keywords
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GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy

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recommendations! Published in 2018 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2018.1436965

Abstract: ABSTRACT Introduction: GATA1, the founding member of a family of transcription factors, plays important roles in the development of hematopoietic cells of several lineages. Although loss of GATA1 has been known to impair hematopoiesis in… read more here.

Keywords: hematopoietic disorders; gata1; primary myelofibrosis; gata1 insufficiencies ... See more keywords
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How I Diagnose Primary Myelofibrosis.

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recommendations! Published in 2022 at "American journal of clinical pathology"

DOI: 10.1093/ajcp/aqac016

Abstract: OBJECTIVES Primary myelofibrosis (PMF) is a BCR/ABL1-negative myeloproliferative neoplasm (MPN) with a shorter overall survival and a higher leukemic transformation than other BCR/ABL1-negative MPNs. Diagnosis of PMF can be challenging given its clinical, morphologic, molecular… read more here.

Keywords: clinical morphologic; pmf; primary myelofibrosis; pathology ... See more keywords