The positive effects of secreting cytokines IL‐17 and IFN‐&ggr; on the early‐stage differentiation and negative effects on the calcification of primary osteoblasts in vitro
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.02.002
Abstract: Objective: Interleukin‐17 (IL‐17) and interferon‐gamma (IFN‐&ggr;) are all pro‐inflammatory cytokines produced by specific subsets of T‐cells and are also considered crucial regulators in bone remodeling, but their effects on osteogenesis have not been carefully studied.… read more here.
Keywords: positive effects; differentiation; primary osteoblasts; early stage ... See more keywords
Different Modulatory Effects of IL-17, IL-22, and IL-23 on Osteoblast Differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/5950395
Abstract: Objectives To examine the expressions of IL-17, IL-22, and IL-23 receptors in four osteoblast models and the effects of IL-17, IL-22, and IL-23 on osteoblasts. Methods Gene expression levels of receptors, alkaline phosphatase (ALP), osteocalcin… read more here.
Keywords: different modulatory; modulatory effects; alp activity; primary osteoblasts ... See more keywords
Metallic wear debris collected from patients induces apoptosis in rat primary osteoblasts via reactive oxygen species-mediated mitochondrial dysfunction and endoplasmic reticulum stress
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DOI: 10.3892/mmr.2019.9825
Abstract: Although total hip arthroplasty is considered to be an effective surgical procedure for treating hip joint diseases, it is hindered by implant wear debris, which induces aseptic loosening. Various cell types are involved in this… read more here.
Keywords: reactive oxygen; metallic wear; wear debris; primary osteoblasts ... See more keywords