Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.3282
Abstract: Importance Clinical trial activity in amyotrophic lateral sclerosis (ALS) is dramatically increasing; as a result, trial modifications have been introduced to improve efficiency, outcome measures have been reassessed, and considerable discussion about the level of… read more here.
Keywords: lateral sclerosis; end points; primary outcome; amyotrophic lateral ... See more keywords
Craniocervical trauma above the age of 90: are current prognostic scores sufficient?
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgical Review"
DOI: 10.1007/s10143-019-01130-3
Abstract: Clinical data following head or spine trauma in patients over 90 years is rare. The aim of this study was to analyze this patient cohort, assessing clinical characteristics, outcomes, and survival rates and to identify variables… read more here.
Keywords: primary outcome; range; age; mortality ... See more keywords
Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nuclear Cardiology"
DOI: 10.1007/s12350-018-01589-5
Abstract: Background Placing the left ventricular (LV) lead in a viable segment with the latest mechanical activation (vSOLA) may be associated with optimal cardiac resynchronization therapy (CRT) response. We assessed the role of gated SPECT myocardial… read more here.
Keywords: primary outcome; outcome; dyssynchrony; gspect mpi ... See more keywords
Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review.
Sign Up to like & getrecommendations! Published in 2018 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2017.12.011
Abstract: OBJECTIVES The primary objective of this systematic survey was to examine the percentage of studies in which there was agreement in the reporting of the primary outcome between the currently updated version of the clinical… read more here.
Keywords: agreement; primary outcome; clinical trial; agreement reporting ... See more keywords
Assessment of frequency and reporting of design changes among clinical drug trials published in influential medical journals.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of internal medicine"
DOI: 10.1016/j.ejim.2019.08.009
Abstract: BACKGROUND Modifications of primary outcome measures after trial initiation can undermine their scientific validity. We aimed to quantify these changes and to characterize potential predictors in clinical drug trials published in high impact factor general… read more here.
Keywords: medicine; primary outcome; drug trials; clinical drug ... See more keywords
Incidence of Morbidity and Mortality in a Cohort of Congenital Complete Heart Block Patients Followed Over 40 Years.
Sign Up to like & getrecommendations! Published in 2022 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2022.02.019
Abstract: BACKGROUND Congenital Complete Heart Block (CCHB), seen in 1:15,000-20,000 births, commonly requires pacemaker placement by young adulthood. There is limited understanding of cardiac morbidity and mortality. OBJECTIVE Determine long-term incidence of cardiac morbidity and mortality… read more here.
Keywords: morbidity mortality; diagnosis; primary outcome; heart ... See more keywords
Coronary plaque characteristics in computed tomography and 2-year outcomes: The PREDICT study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of cardiovascular computed tomography"
DOI: 10.1016/j.jcct.2018.07.001
Abstract: BACKGROUND Coronary computed tomography angiography (CCTA) not only provides information regarding luminal stenoses but also allows for visualization of mural atheromatous changes (coronary plaques). OBJECTIVE We sought to elucidate whether plaques seen on CCTA enable… read more here.
Keywords: primary outcome; computed tomography; ccta; year ... See more keywords
Efficacy of psychotherapies and pharmacotherapies for Bulimia nervosa
Sign Up to like & getrecommendations! Published in 2018 at "Psychological Medicine"
DOI: 10.1017/s0033291718003525
Abstract: Abstract Background Bulimia nervosa (BN), a mental disorder that causes significant impairment, can be treated with psychological, pharmacological, nutrition-based and self-help interventions. We conducted a pre-registered meta-analysis of randomized-controlled trials (RCTs) to assess the efficacy… read more here.
Keywords: primary outcome; self help; outcome variables; bulimia nervosa ... See more keywords
Differences in the prognoses of patients referred to an advanced heart failure center from hospitals with different bed volumes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-78162-z
Abstract: Few reports have discussed appropriate strategies for patient referrals to advanced heart failure (HF) centers with available left ventricular assist devices (LVADs). We examined the association between the characteristics and prognoses of referred patients with… read more here.
Keywords: primary outcome; bed volume; center; patients referred ... See more keywords
Analysis of study designs and primary outcome measures in clinical trials of investigational suture materials
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Medical Devices"
DOI: 10.1080/17434440.2022.2054333
Abstract: ABSTRACT Background Clinical trials are a prerequisite for any investigational suture materials before a market approval application. The appropriate study designs and primary outcome measures are key to the validity and reliability of clinical trial… read more here.
Keywords: investigational suture; primary outcome; suture materials; outcome measures ... See more keywords
Development of a Composite Primary Outcome Score for Children with Attention-Deficit/Hyperactivity Disorder and Emotional Dysregulation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of child and adolescent psychopharmacology"
DOI: 10.1089/cap.2019.0179
Abstract: Objective: Study goals were to (1) provide a rationale for developing a composite primary outcome score that includes symptom severity for attention-deficit/hyperactivity disorder (ADHD) and emotional dysregulation, plus symptom-induced impairment; (2) demonstrate weighting methods to… read more here.
Keywords: primary outcome; emotional dysregulation; composite primary; weighting methods ... See more keywords