Primary plasma cell leukemia in the era of novel agents for myeloma - a multicenter retrospective analysis of outcome.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.02.010
Abstract: Primary plasma cell leukemia (PPCL) is a rare form of multiple myeloma with a dismal prognosis. This retrospective multi-center study examines the national experience of PPCL in the era of novel agents. During 2002-2016, thirty-nine… read more here.
Keywords: primary plasma; cell leukemia; novel agents; plasma cell ... See more keywords
Global methylation patterns in primary plasma cell leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.09.007
Abstract: Primary plasma cell leukemia (pPCL) is a rare and very aggressive variant of multiple myeloma (MM). Specific clinical, biological and molecular patterns distinguish pPCL from MM. Here, we performed a genome-wide methylation analysis by high-density… read more here.
Keywords: ppcl; primary plasma; methylation; cell leukemia ... See more keywords
Transcriptome analysis reveals significant differences between primary plasma cell leukemia and multiple myeloma even when sharing a similar genetic background
Sign Up to like & getrecommendations! Published in 2019 at "Blood Cancer Journal"
DOI: 10.1038/s41408-019-0253-1
Abstract: Primary plasma cell leukemia (pPCL) is a highly aggressive plasma cell dyscrasia characterised by short remissions and very poor survival. Although the 17p deletion is associated with poor outcome and extramedullary disease in MM, its… read more here.
Keywords: primary plasma; significant differences; analysis; plasma cell ... See more keywords
Primary Plasma Cell Leukemia displaying t(11;14) have specific genomic, transcriptional and clinical feature.
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DOI: 10.1182/blood.2021014968
Abstract: Primary plasma cell leukemia (pPCL) is an aggressive form of multiple myeloma (MM) that has not benefited from recent therapeutic advances in the field. Because very rare and heterogeneous, it remains poorly understood at the… read more here.
Keywords: specific genomic; plasma cell; cell leukemia; plasma ... See more keywords
Coexistence of Acute Promyelocytic Leukemia and Primary Plasma Cell Leukemia: Careful Consideration in Diagnosis
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DOI: 10.3343/alm.2022.42.2.278
Abstract: Dear Editor, Acute promyelocytic leukemia (APL) is frequently associated with disseminated intravascular coagulation (DIC) and hemorrhage, which contributes to its high mortality rate [1]. Molecular confirmation for identifying a PML-RARA rearrangement has to be performed… read more here.
Keywords: cell; promyelocytic leukemia; leukemia; plasma cell ... See more keywords
Transcriptomic Analysis in Multiple Myeloma and Primary Plasma Cell Leukemia with t(11;14) Reveals Different Expression Patterns with Biological Implications in Venetoclax Sensitivity
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13194898
Abstract: Simple Summary The growing interest in BCL2 inhibitors for the treatment of multiple myeloma (MM) has led to the need for biomarkers that are able to predict patient’s sensitivity to the drug. The presence of… read more here.
Keywords: primary plasma; cell leukemia; plasma cell; sensitivity ... See more keywords