Brain atrophy and disability worsening in primary progressive multiple sclerosis: insights from the INFORMS study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.534
Abstract: To investigate the relationship between brain volume and disability worsening over ≥3 years in the natural history of primary progressive multiple sclerosis using data from the placebo group of the INFORMS trial (n = 487;… read more here.
Keywords: progressive multiple; multiple sclerosis; disability worsening; primary progressive ... See more keywords
Unravelling neurotransmitters impairment in primary progressive aphasias
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26206
Abstract: Primary progressive aphasias (PPAs) are a group of neurodegenerative diseases mainly characterized by language impairment, and with variably presence of dysexecutive syndrome, behavioural disturbances and parkinsonism. Detailed knowledge of neurotransmitters impairment and its association with… read more here.
Keywords: primary progressive; progressive aphasias; neurotransmitters impairment; impairment primary ... See more keywords
Unraveling the MRI‐Based Microstructural Signatures Behind Primary Progressive and Relapsing–Remitting Multiple Sclerosis Phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27806
Abstract: The mechanisms driving primary progressive and relapsing–remitting multiple sclerosis (PPMS/RRMS) phenotypes are unknown. Magnetic resonance imaging (MRI) studies support the involvement of gray matter (GM) in the degeneration, highlighting its damage as an early feature… read more here.
Keywords: progressive relapsing; primary progressive; relapsing remitting; remitting multiple ... See more keywords
Primary progressive aphasia: a clinical approach
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurology"
DOI: 10.1007/s00415-018-8762-6
Abstract: The primary progressive aphasias are a heterogeneous group of focal ‘language-led’ dementias that pose substantial challenges for diagnosis and management. Here we present a clinical approach to the progressive aphasias, based on our experience of… read more here.
Keywords: progressive aphasia; clinical approach; primary progressive; aphasia clinical ... See more keywords
Primary Progressive Aphasia: Toward a Pathophysiological Synthesis
Sign Up to like & getrecommendations! Published in 2021 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-021-01097-z
Abstract: Purpose of Review The term primary progressive aphasia (PPA) refers to a diverse group of dementias that present with prominent and early problems with speech and language. They present considerable challenges to clinicians and researchers.… read more here.
Keywords: variant ppa; ppa; primary progressive; progressive aphasia ... See more keywords
Ocrelizumab for Treating Patients with Primary Progressive Multiple Sclerosis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
Sign Up to like & getrecommendations! Published in 2020 at "PharmacoEconomics"
DOI: 10.1007/s40273-020-00889-4
Abstract: Ocrelizumab is indicated for relapsing remitting and primary progressive multiple sclerosis (RRMS and PPMS, respectively). In an appraisal undertaken by the National Institute for Health and Care Excellence (NICE), the company Roche presented the evidence… read more here.
Keywords: disability; progressive multiple; group; evidence ... See more keywords
Data-driven classification of patients with primary progressive aphasia
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Language"
DOI: 10.1016/j.bandl.2017.08.001
Abstract: Highlights • There is current controversy over how to classify PPA variants.• We used a k-means clustering algorithm, blind to diagnosis, to divide patients.• Patients grouped based on similarities in linguistic and neuropsychological profile.• One… read more here.
Keywords: classification patients; data driven; driven classification; patients primary ... See more keywords
Prosodic and phonetic subtypes of primary progressive apraxia of speech
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Language"
DOI: 10.1016/j.bandl.2018.06.004
Abstract: HighlightsPhonetic PPAOS is characterized predominantly by distorted sound substitutions.Prosodic PPAOS is characterized predominantly by slow, segmented speech.The predominant clinical characteristics of PPAOS can be quantified reliably.PPAOS subtypes are associated with distinct imaging patterns on MRI,… read more here.
Keywords: speech; apraxia speech; primary progressive; ppaos characterized ... See more keywords
Effects of concurrent action and object naming treatment on naming skills and functional brain activation patterns in primary progressive aphasia: An fMRI study with a case-series design
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Language"
DOI: 10.1016/j.bandl.2021.104950
Abstract: Individuals with primary progressive aphasia (PPA) exhibit differential impairment patterns in noun and verb naming, but it remains unclear whether anomia treatment results in similar improvements in noun and verb naming. Therefore, we examined the… read more here.
Keywords: treatment; case series; naming skills; primary progressive ... See more keywords
A new paraplegin mutation in a patient with primary progressive multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102302
Abstract: Primary progressive multiple sclerosis (PPMS) presents with clinical signs of slowly progressive long tract dysfunction that can overlap with neurodegenerative disorders, such as hereditary spastic paraplegia (HSP). Herein, we present two siblings in whom we… read more here.
Keywords: progressive multiple; multiple sclerosis; primary progressive; mutation ... See more keywords
Increased socioeconomic burden in patients with primary progressive multiple sclerosis: A Danish nationwide population-based study.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102567
Abstract: BACKGROUND Primary progressive multiple sclerosis (PPMS) is characterized by development of more chronic neurological manifestations from disease onset compared with relapsing remitting MS (RRMS) and secondary progressive MS (SPMS) but the following socioeconomic consequences have… read more here.
Keywords: sclerosis; multiple sclerosis; primary progressive; socioeconomic burden ... See more keywords