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   Articles with "primary rat" as a keyword



Exposing primary rat retina cell cultures to &ggr;‐rays: An in vitro model for evaluating radiation responses

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recommendations! Published in 2018 at "Experimental Eye Research"

DOI: 10.1016/j.exer.2017.09.009

Abstract: ABSTRACT Retinal tissue can receive incidental &ggr;‐rays exposure during radiotherapy either of tumors of the eye and optic nerve or of head‐and‐neck tumors, and during medical diagnostic procedures. Healthy retina is therefore at risk of… read more here.

Keywords: vitro model; ggr rays; cell; retina ... See more keywords

The effects and possible mechanisms of triclosan on steroidogenesis in primary rat granulosa cells.

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recommendations! Published in 2019 at "Reproductive toxicology"

DOI: 10.1016/j.reprotox.2018.11.001

Abstract: BACKGROUND Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking. METHODS Primary rat granulosa cells (rGCs) were… read more here.

Keywords: granulosa cells; rat granulosa; primary rat; steroidogenesis ... See more keywords

Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ.

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recommendations! Published in 2019 at "Toxicology"

DOI: 10.1016/j.tox.2019.152248

Abstract: Methylmercury (MeHg) is a ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. Curcumin, a polyphenol obtained from the rhizome of turmeric, has well-known antioxidant functions. Here, we evaluated curcumin's efficacy… read more here.

Keywords: curcumin; nrf2 pathway; induced cytotoxicity; mehg induced ... See more keywords
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Mechanistic Approach for Toxic Effects of Bupropion in Primary Rat Hepatocytes.

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recommendations! Published in 2017 at "Drug research"

DOI: 10.1055/s-0042-123034

Abstract: Bupropion is a widely prescribed antidepressant/smoke cessation drug. However, hepatotoxicity is one of its side effects reported in some recipients. The mechanisms by which bupropion induces hepatotoxicity is not clear yet. This experiment was intended… read more here.

Keywords: rat hepatocytes; alpha tos; bupropion; mechanistic approach ... See more keywords

Dimethyl itaconate modulates neuroprotective effect on primary rat astrocytes under inflammatory condition by regulating the expression of neurotrophic factors and TrkA/B-P75 receptors

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recommendations! Published in 2024 at "Neurological Research"

DOI: 10.1080/01616412.2024.2423583

Abstract: ABSTRACT Introduction Astrocytes, specialized glial cells, are essential for maintaining the central nervous system homeostasis. Inflammatory conditions can disrupt neurotrophic factors and receptor expression in astrocytes, leading to potential central nervous system damage. Itaconate, recently… read more here.

Keywords: neurotrophic factors; astrocyte; primary rat; expression ... See more keywords

The Proliferative and Functional Roles of CEBP/A in Ins-1 832/13 Cells and Primary Rat Islets

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5733656

Abstract: The beta cell transcription factor Nkx6.1, when overexpressed in primary rodent and human islets, is sufficient to enhance beta cell proliferation, increase insulin secretion and enhance cell survival. We have sought to define the transcriptional… read more here.

Keywords: cell; primary rat; 832 cells; ins 832 ... See more keywords

Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells

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recommendations! Published in 2017 at "Cellular Physiology and Biochemistry"

DOI: 10.1159/000460513

Abstract: Background/Aims: Neuroinflammatory processes have been implicated in the pathophysiology of seizure/epilepsy. High mobility group box 1 (HMGB1), a non-histone DNA binding protein, behaves like an inflammatory cytokine in response to epileptogenic insults. Kainic acid (KA)… read more here.

Keywords: hmgb1; epilepsy; primary rat; extracellular hmgb1 ... See more keywords

Impact of hyperbilirubinemia on rat cardiomyocyte injury

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recommendations! Published in 2025 at "BMC Cardiovascular Disorders"

DOI: 10.1186/s12872-025-04859-6

Abstract: To investigate bilirubin-induced injury in rat myocardial cells at varying concentrations. The study utilized the rat cardiomyocyte cell line H9C2 and primary rat cardiomyocytes. Bilirubin-rich and control sera were prepared, and cells were cultured for… read more here.

Keywords: rat; rat cardiomyocyte; bilirubin induced; primary rat ... See more keywords

Development and application of primary rat parathyroid cells for transplantation in hypoparathyroidism

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recommendations! Published in 2025 at "Gland Surgery"

DOI: 10.21037/gs-24-411

Abstract: Background Hypoparathyroidism (HPO) is characterized by deficient secretion of parathyroid hormone (PTH), leading to hypocalcemia and disrupted calcium homeostasis. Current treatments rely on calcium and vitamin D supplementation, which do not adequately mimic physiological PTH… read more here.

Keywords: primary rat; rat parathyroid; culture; parathyroid ... See more keywords

Nrdp1 Increases Ischemia Induced Primary Rat Cerebral Cortical Neurons and Pheochromocytoma Cells Apoptosis Via Downregulation of HIF-1α Protein

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recommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2017.00293

Abstract: Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that targets proteins for degradation and regulates cell growth, apoptosis and oxidative stress in various cell types. We have previously shown that Nrdp1 is implicated… read more here.

Keywords: protein; hif; apoptosis; rat cerebral ... See more keywords

The interplay of intracellular calcium and zinc ions in response to electric field stimulation in primary rat cortical neurons in vitro

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recommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2023.1118335

Abstract: Recent pharmacological studies demonstrate a role for zinc (Zn2+) in shaping intracellular calcium (Ca2+) dynamics and vice versa in excitable cells including neurons and cardiomyocytes. Herein, we sought to examine the dynamic of intracellular release… read more here.

Keywords: rat cortical; ca2 zn2; intracellular calcium; primary rat ... See more keywords