Exposing primary rat retina cell cultures to &ggr;‐rays: An in vitro model for evaluating radiation responses
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.09.009
Abstract: ABSTRACT Retinal tissue can receive incidental &ggr;‐rays exposure during radiotherapy either of tumors of the eye and optic nerve or of head‐and‐neck tumors, and during medical diagnostic procedures. Healthy retina is therefore at risk of… read more here.
Keywords: vitro model; ggr rays; cell; retina ... See more keywords
The effects and possible mechanisms of triclosan on steroidogenesis in primary rat granulosa cells.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.11.001
Abstract: BACKGROUND Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking. METHODS Primary rat granulosa cells (rGCs) were… read more here.
Keywords: granulosa cells; rat granulosa; primary rat; steroidogenesis ... See more keywords
Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.152248
Abstract: Methylmercury (MeHg) is a ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. Curcumin, a polyphenol obtained from the rhizome of turmeric, has well-known antioxidant functions. Here, we evaluated curcumin's efficacy… read more here.
Keywords: curcumin; nrf2 pathway; induced cytotoxicity; mehg induced ... See more keywords
Mechanistic Approach for Toxic Effects of Bupropion in Primary Rat Hepatocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Drug research"
DOI: 10.1055/s-0042-123034
Abstract: Bupropion is a widely prescribed antidepressant/smoke cessation drug. However, hepatotoxicity is one of its side effects reported in some recipients. The mechanisms by which bupropion induces hepatotoxicity is not clear yet. This experiment was intended… read more here.
Keywords: rat hepatocytes; alpha tos; bupropion; mechanistic approach ... See more keywords
The Proliferative and Functional Roles of CEBP/A in Ins-1 832/13 Cells and Primary Rat Islets
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733656
Abstract: The beta cell transcription factor Nkx6.1, when overexpressed in primary rodent and human islets, is sufficient to enhance beta cell proliferation, increase insulin secretion and enhance cell survival. We have sought to define the transcriptional… read more here.
Keywords: cell; primary rat; 832 cells; ins 832 ... See more keywords
Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000460513
Abstract: Background/Aims: Neuroinflammatory processes have been implicated in the pathophysiology of seizure/epilepsy. High mobility group box 1 (HMGB1), a non-histone DNA binding protein, behaves like an inflammatory cytokine in response to epileptogenic insults. Kainic acid (KA)… read more here.
Keywords: hmgb1; epilepsy; primary rat; extracellular hmgb1 ... See more keywords
Nrdp1 Increases Ischemia Induced Primary Rat Cerebral Cortical Neurons and Pheochromocytoma Cells Apoptosis Via Downregulation of HIF-1α Protein
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00293
Abstract: Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that targets proteins for degradation and regulates cell growth, apoptosis and oxidative stress in various cell types. We have previously shown that Nrdp1 is implicated… read more here.
Keywords: protein; hif; apoptosis; rat cerebral ... See more keywords
The interplay of intracellular calcium and zinc ions in response to electric field stimulation in primary rat cortical neurons in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1118335
Abstract: Recent pharmacological studies demonstrate a role for zinc (Zn2+) in shaping intracellular calcium (Ca2+) dynamics and vice versa in excitable cells including neurons and cardiomyocytes. Herein, we sought to examine the dynamic of intracellular release… read more here.
Keywords: rat cortical; ca2 zn2; intracellular calcium; primary rat ... See more keywords
Regulatory Effects of Metformin, an Antidiabetic Biguanide Drug, on the Metabolism of Primary Rat Adipocytes
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165250
Abstract: Metformin is a biguanide compound commonly applied in humans with type 2 diabetes. The drug affects different tissues, including fat tissue. The direct influence of metformin on cells of fat tissue, i.e., adipocytes, is poorly… read more here.
Keywords: primary rat; rat adipocytes; metabolism primary; drug ... See more keywords