Diagnosis and Management of Osteoarticular Tuberculosis: A Drastic Change in Mind Set Needed-It is Not Enough to Simply Diagnose TB.
Sign Up to like & getrecommendations! Published in 2020 at "Indian journal of orthopaedics"
DOI: 10.1007/s43465-020-00202-7
Abstract: Background In the era of increasing drug resistance in pulmonary tuberculosis (TB), it is prudent to assess causes of poor response to anti tubercular therapy (ATT) and drug sensitivity pattern (DSP) in osteoarticular TB. Materials… read more here.
Keywords: diagnosis management; management osteoarticular; primary resistance; tuberculosis ... See more keywords
The Efficacy of Lenvatinib Plus Everolimus in Patients with Metastatic Renal Cell Carcinoma Exhibiting Primary Resistance to Front-Line Targeted Therapy or Immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical genitourinary cancer"
DOI: 10.1016/j.clgc.2020.03.003
Abstract: BACKGROUND Patients with primary refractory metastatic renal cell carcinoma (mRCC) have a dismal prognosis and poor response to subsequent treatments. While there are several approved second-line therapies, it remains critical to choose the most effective… read more here.
Keywords: lenvatinib plus; line; plus everolimus; primary resistance ... See more keywords
A large scale proteome analysis of the gefitinib primary resistance overcome by KDAC inhibition in KRAS mutated adenocarcinoma cells overexpressing amphiregulin.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.01.009
Abstract: KDAC inhibitors (KDACi) overcome gefitinib primary resistance in non-small cell lung cancer (NSCLC) including mutant-KRAS lung adenocarcinoma. To identify which proteins are involved in the restoration of this sensitivity and to provide new therapeutic targets… read more here.
Keywords: kras mutated; gefitinib; kdac; primary resistance ... See more keywords
An In Sitro Assay to Predict Primary Resistance to PD-1 Blockade.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2021.01.006
Abstract: Immune check point inhibition (ICI) is a paradigm shift in oncology, but most patients treated with ICI will not respond to treatment. Thus, the need for predictive biomarkers for ICI is high. Dubuisson and colleagues… read more here.
Keywords: resistance blockade; predict primary; primary resistance; assay predict ... See more keywords
Potential mechanism of primary resistance to icotinib in patients with advanced non–small cell lung cancer harboring uncommon mutant epidermal growth factor receptor: A multi‐center study
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14277
Abstract: The incidence of epidermal growth factor receptor uncommon mutation (EGFRum) is relatively low and patients harboring EGFRum are resistant to the first‐generation tyrosine kinase inhibitors (TKI). However, the mechanism of primary resistance remains unclear. Medical… read more here.
Keywords: icotinib; primary resistance; resistance; amplification ... See more keywords
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004703
Abstract: Background Gastrointestinal (GI) cancer is the second most common cancer type with mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) phenotype that is expected to respond to immune-checkpoint inhibitors (ICIs). However, approximately half of the patients with dMMR/MSI-H… read more here.
Keywords: primary resistance; dmmr msi; icis; cancer ... See more keywords
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-16-1223
Abstract: Loss-of-function mutations in JAK1/2 can lead to acquired resistance to anti-programmed death protein 1 (PD-1) therapy. We reasoned that they may also be involved in primary resistance to anti-PD-1 therapy. JAK1/2-inactivating mutations were noted in… read more here.
Keywords: blockade; primary resistance; jak1 mutations; resistance ... See more keywords
Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-22-0886
Abstract: Cancer cell genomic instability correlates with proinflammatory IL6 and IL8 production, VEGF, as well as regulatory T cells and is associated with primary resistance to immunotherapy and antiangiogenics in patients with advanced mesothelioma. read more here.
Keywords: primary resistance; genomic instability; instability protumoral; associated primary ... See more keywords
BMI, irAE, and gene expression signatures associate with resistance to immune-checkpoint inhibition and outcomes in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-02144-7
Abstract: BackgroundClinical variables may correlate with lack of response to treatment (primary resistance) or clinical benefit in patients with clear cell renal cell carcinoma (ccRCC) treated with anti-programmed death 1/ligand one antibodies.MethodsIn this multi-institutional collaboration, clinical… read more here.
Keywords: clinical benefit; bmi; gene expression; primary resistance ... See more keywords
Mechanisms of primary resistance to icotinib in Chinese non-small-cell lung cancer patients with EGFR uncommon mutations: A multicenter study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e20501
Abstract: e20501 Background: Previous case series, retrospective studies and pooled survey studies have investigated the clinical efficacies of EGFR-TKIs in patients harboring EGFR uncommon mutations. However, part of patients with EGFR uncommon mutations do not exhibit… read more here.
Keywords: primary resistance; uncommon mutations; resistance icotinib; egfr uncommon ... See more keywords
Plasma microRNA alterations between EGFR-activating mutational NSCLC patients with and without primary resistance to TKI
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19874
Abstract: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have obtained excellent therapeutic effects against non-small cell lung cancer (NSCLC) harboring activating EGFR mutations. However, some patients have exhibited primary resistance which becomes a major… read more here.
Keywords: hsa mir; nsclc; hsa; primary resistance ... See more keywords