Why Therapeutic Trials Fail in Primary Tauopathies
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29322
Abstract: Primary tauopathies are neurodegenerative diseases in which tau protein aggregates constitute the main underlying neuropathological process. Tau proteins are a group of six isomers that bind to and stabilize microtubules and play a role in… read more here.
Keywords: fail primary; disease; trials fail; therapeutic trials ... See more keywords
Disease-modifying therapies for tauopathies: agents in the pipeline
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2019.1606715
Abstract: ABSTRACT Introduction: Tauopathies are heterogeneous clinicopathological entities characterized by abnormal neuronal and/or glial inclusions of the microtubule-binding protein tau. Primary tauopathies considered to be diseases correspond to a major class of frontotemporal lobar degeneration (FTLD)… read more here.
Keywords: tau; modifying therapies; primary tauopathies; disease modifying ... See more keywords