CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2039-2
Abstract: The immune checkpoint receptor CTLA-4 plays a crucial part in negatively regulating T cell activation and maintaining self-tolerance. It is frequently overexpressed in a variety of malignancies, yet its prognostic impact in non-small cell lung… read more here.
Keywords: ctla expression; primary tumors; expression; prognostic impact ... See more keywords
Preferential expression of NY-BR-1 and GATA-3 in male breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-017-2542-z
Abstract: BackgroundMale breast cancer is an uncommon disease often discovered in advanced stage; thus, in the setting of metastatic adenocarcinoma, breast origin must be taken to account. Breast markers as NY-BR-1, GATA-3, mammaglobin, and BRST-2 are… read more here.
Keywords: male breast; breast; breast cancer; primary tumors ... See more keywords
Targeted deep sequencing helps distinguish independent primary tumors from intrapulmonary metastasis for lung cancer diagnosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03227-5
Abstract: Multiple lung lesions found in a single patient at the time of diagnosis often pose a diagnostic dilemma: are these lesions independent primary tumors (IPT) or the result of intrapulmonary metastases (IPM)? While traditional pathological… read more here.
Keywords: independent primary; diagnosis; targeted deep; metastasis ... See more keywords
Primary tumors of the posterior pituitary: A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-019-09484-1
Abstract: In 2017, the World Health Organization established that pituicytoma, granular cell tumor (GCT), spindle cell oncocytoma (SCO) and sellar ependymomas (SE) are posterior pituitary tumors (PPT). They probably arise from the pituicytes and may constitute… read more here.
Keywords: systematic review; posterior pituitary; primary tumors; tumors posterior ... See more keywords
Diagnosis and Treatment of Primary Tumors of the Appendix: a Critical Review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-021-00628-8
Abstract: The aim of the current paper was to critically collect, select and summarize the evidence regarding diagnosis, treatment and follow up of primary tumors of the appendix. A literature review was performed by search and… read more here.
Keywords: diagnosis treatment; primary tumors; review; tumors appendix ... See more keywords
Next-generation sequencing based detection of germline and somatic alterations in a patient with four metachronous primary tumors
Sign Up to like & getrecommendations! Published in 2018 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2018.04.004
Abstract: Introduction Multiple primary tumors (MPTs) are defined as two or more separate synchronous or metachronous neoplasms occurring in different sites in the same individual. These tumors differ in histology, as well as primary sites from… read more here.
Keywords: metachronous primary; primary tumors; germline; four metachronous ... See more keywords
Risk of second primary tumors in GIST survivors: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Surgical oncology"
DOI: 10.1016/j.suronc.2019.03.001
Abstract: INTRODUCTION Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising in the gastrointestinal tract. Second primary tumors (SPTs) have been reported frequently, either synchronously or during follow-up, in patients diagnosed with GISTs. METHODS We carried… read more here.
Keywords: second primary; meta analysis; risk; primary tumors ... See more keywords
ESR1 methylation in primary tumors and paired circulating tumor DNA of patients with high-grade serous ovarian cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2018.05.026
Abstract: OBJECTIVE Estrogen receptor, coded by the ESR1 gene, is highly expressed in epithelial ovarian cancer. ESR1 gene is frequently methylated in many types of gynecological malignancies. However, only a few studies attempted to investigate the… read more here.
Keywords: primary tumors; methylation; esr1 methylation; ovarian cancer ... See more keywords
Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27017-w
Abstract: Metastatic cancer is associated with poor patient prognosis but its spatiotemporal behavior remains unpredictable at early stage. Here we develop MetaNet, a computational framework that integrates clinical and sequencing data from 32,176 primary and metastatic… read more here.
Keywords: risk; machine learning; learning genomic; primary tumors ... See more keywords
Deciphering clonal dynamics and metastatic routines in a rare patient of synchronous triple-primary tumors and multiple metastases with MPTevol
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac175
Abstract: Multiple primary tumor (MPT) is a special and rare cancer type, defined as more than two primary tumors presenting at the diagnosis in a single patient. The molecular characteristics and tumorigenesis of MPT remain unclear… read more here.
Keywords: triple primary; clonal dynamics; metastatic routines; rare patient ... See more keywords
Patient demographics, tumor characteristics, and outcomes following surgical treatment of benign and malignant brachial plexus tumors: a systematic review.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgery"
DOI: 10.1097/js9.0000000000000309
Abstract: BACKGROUND Various treatment options have been introduced for the management of primary tumors of the brachial plexus (BP), ranging from conservative therapy to wide local excision with/without postoperative chemoradiotherapy. However, no consensus exists regarding optimal… read more here.
Keywords: brachial plexus; surgical treatment; benign malignant; primary tumors ... See more keywords