Relapses and outcomes of systemic chemo-free therapies combined with intravitreous methotrexate in isolated primary vitreoretinal lymphoma: an analysis based on two prospective cohort studies
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DOI: 10.1007/s00277-025-06414-x
Abstract: The definitive therapeutic paradigm for primary vitreoretinal lymphoma (PVRL) remains controversial, with ongoing debates surrounding the comparative efficacy of localized ocular therapy, high-dose systemic chemotherapy, and combined-modality approaches. The benefit of systemic administration of methotrexate… read more here.
Keywords: vitreoretinal lymphoma; chemo free; systemic chemo; primary vitreoretinal ... See more keywords
A noninvasive machine learning model using a complete blood count for screening of primary vitreoretinal lymphoma
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DOI: 10.1038/s41467-025-65693-0
Abstract: Primary vitreoretinal lymphoma (PVRL) is a rare and aggressive intraocular malignancy that is frequently misdiagnosed because of its nonspecific early manifestations and the lack of effective screening tools. We conduct a multicentre case–control study including… read more here.
Keywords: primary vitreoretinal; machine learning; vitreoretinal lymphoma; model ... See more keywords
Hyper-N-glycosylated SEL1L3 as auto-antigenic B-cell receptor target of primary vitreoretinal lymphomas
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DOI: 10.1038/s41598-024-60169-5
Abstract: Primary vitreoretinal lymphoma (PVRL) is a rare subtype of DLBCL and can progress into primary central nervous system lymphoma (PCNSL). To investigate the role of chronic antigenic stimulation in PVRL, we cloned and expressed B-cell… read more here.
Keywords: auto; pvrl; primary vitreoretinal; cell ... See more keywords
Clinical Outcomes in Vitrectomized versus Non-vitrectomized Eyes in Patients with Primary Vitreoretinal Lymphoma
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DOI: 10.1080/09273948.2022.2033794
Abstract: ABSTRACT Aim To evaluate if there is a difference in the clinical course of primary vitreoretinal lymphoma (PVRL) in vitrectomized versus non-vitrectomized eyes. Methods Observational multicenter retrospective case series of patients diagnosed with PVRL between… read more here.
Keywords: vitrectomized eyes; non vitrectomized; vitreoretinal lymphoma; versus non ... See more keywords
An international real‐world study of primary vitreoretinal lymphoma from the Australasian lymphoma alliance and collaborators
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DOI: 10.1111/bjh.20115
Abstract: Primary vitreoretinal lymphoma (PVRL) is a high‐grade extranodal non‐Hodgkin lymphoma, with limited prospective data to inform practice. High rates of central nervous system (CNS) relapse contribute to its poor prognosis. This international multicentre retrospective cohort… read more here.
Keywords: real world; primary vitreoretinal; vitreoretinal lymphoma; lymphoma ... See more keywords
Primary Vitreoretinal Lymphoma: A Retrospective Study of 20 Eyes
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DOI: 10.1155/2022/4522974
Abstract: Purpose This study aimed to describe and analyze the clinical features of 20 eyes of 15 primary vitreoretinal lymphoma (PVRL) patients. Methods This was a retrospective case series and a review of the literature. Fifteen… read more here.
Keywords: study; vitreoretinal lymphoma; wool spots; primary vitreoretinal ... See more keywords
Clinical outcomes following intravitreal methotrexate for primary vitreoretinal lymphoma
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DOI: 10.1186/s40942-021-00346-0
Abstract: Purpose To describe the visual acuity and anatomic outcomes of intravitreal methotrexate (MTX) for the treatment of primary vitreoretinal lymphoma (PVRL). Methods Single-center retrospective case series of patients with a diagnosis of PVRL treated with… read more here.
Keywords: time; intravitreal methotrexate; lymphoma; treatment ... See more keywords
Primary Vitreoretinal Lymphoma: Current Diagnostic Laboratory Tests and New Emerging Molecular Tools
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DOI: 10.3390/curroncol29100543
Abstract: Primary vitreoretinal lymphoma (PVRL), a rare aggressive malignancy primarily involving the retina and/or the vitreous, is a major diagnostic challenge for clinicians (who commonly misdiagnose it as chronic uveitis) as well as for pathologists (for… read more here.
Keywords: lymphoma; vitreoretinal lymphoma; diagnosis; new emerging ... See more keywords