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2
Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00100
Abstract: DNA synthesis during replication begins with the generation of an ∼10-nucleotide primer by DNA primase. Primase contains a redox-active 4Fe-4S cluster in the C-terminal domain of the p58 subunit (p58C). The redox state of this…
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Keywords:
4fe cluster;
primase;
dna;
charge transport ... See more keywords
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Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b01273
Abstract: The interface between the DnaG primase C-terminal domain (CTD) and the N-terminal domain of DnaB helicase is essential for bacterial DNA replication because it allows coordinated priming of DNA synthesis at the replication fork while…
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Keywords:
terminal domain;
ctd;
primase;
conformation ... See more keywords
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1
Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c05928
Abstract: The widespread use of antibiotics to treat infections is one of the reasons that global mortality rates have fallen over the past 80 years. However, antibiotic use is also responsible for the concomitant rise in…
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Keywords:
theoretical development;
primase novel;
development dnag;
novel narrow ... See more keywords
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3
Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28093-2
Abstract: Replicative DNA polymerases cannot initiate DNA synthesis de novo and rely on dedicated RNA polymerases, primases, to generate a short primer. This primer is then extended by the DNA polymerase. In diverse archaeal species, the…
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Keywords:
dna;
dna polymerase;
primer;
primase ... See more keywords
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1
Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2113873
Abstract: ABSTRACT Helicase-primase is an interesting target for small-molecule therapy of herpes simplex virus (HSV) infections. With amenamevir already approved for varicella-zoster virus and with pritelivir’s granted breakthrough therapy designation for the treatment of acyclovir-resistant HSV…
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Keywords:
simplex virus;
drug candidate;
phaeno therapeutics;
helicase primase ... See more keywords
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Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab956
Abstract: Abstract DNA–protein interactions play essential roles in all living cells. Understanding of how features embedded in the DNA sequence affect specific interactions with proteins is both challenging and important, since it may contribute to finding…
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Keywords:
protein interactions;
dna;
inferring primase;
dna protein ... See more keywords
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2
Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad261
Abstract: Abstract The marine thermophilic archaeon Nanoarchaeum equitans possesses a monomeric primase encompassing the conserved domains of the small catalytic and the large regulatory subunits of archaeoeukaryotic heterodimeric primases in one protein chain. The recombinant protein…
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Keywords:
monomeric archaeal;
nanoarchaeum equitans;
heterodimeric archaeoeukaryotic;
archaeoeukaryotic primases ... See more keywords
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1
Published in 2017 at "Science"
DOI: 10.1126/science.aan2762
Abstract: Baranovskiy et al. and Pellegrini argue that, based on structural data, the path for charge transfer through the [4Fe4S] domain of primase is not feasible. Our manuscript presents electrochemical data directly showing charge transport through…
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Keywords:
charge transport;
dna;
charge;
primase ... See more keywords
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Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.766612
Abstract: PrimPols are a class of primases that belong to the archaeo-eukaryotic primase (AEP) superfamily but have both primase and DNA polymerase activities. Replicative polymerase from NrS-1 phage (NrSPol) is a representative of the PrimPols. In…
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Keywords:
primase polymerase;
dna polymerase;
polymerase activities;
primase ... See more keywords