Characterization of twin-cysteine motif in the V2-loop region of gp120 in primate lentiviruses.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.04.013
Abstract: The twin-cysteine motif (TCM) in the V2 loop region of gp120, identified in our previous report on the simian immunodeficiency virus mac239 (SIVmac239), is a conserved evolutionary element in all primate lentiviruses except for HIV-1… read more here.
Keywords: cysteine motif; region gp120; primate lentiviruses; twin cysteine ... See more keywords
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2025914118
Abstract: Significance The CD4 protein of primates has undergone rapid diversification, but the reasons for this remain unknown. Here we show that within-species diversity of the HIV/simian immunodeficiency virus (SIV) envelope (Env) binding (D1) domain is… read more here.
Keywords: cd4 receptor; diversity; primate lentiviruses; primate ... See more keywords
Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation
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DOI: 10.1371/journal.ppat.1006598
Abstract: Primate lentiviruses have evolved sophisticated strategies to suppress the immune response of their host species. For example, HIV-2 and most simian immunodeficiency viruses (SIVs) use their accessory protein Nef to prevent T cell activation and… read more here.
Keywords: strategies suppress; least three; primate lentiviruses; three alternative ... See more keywords