Evolution and emergence of primate‐specific interferon regulatory factor 9
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28521
Abstract: The binding of interferon (IFN) to its receptors leads to formation of IFN‐stimulated gene factor 3 (ISGF3) complex that activates the transcription of cellular IFN‐regulated genes. IFN regulatory factor 9 (IRF9, also called ISGF3γ or… read more here.
Keywords: canonical irf9; primate specific; irf9; regulatory factor ... See more keywords
A Primate-Specific Isoform of PLEKHG6 Regulates Neurogenesis and Neuronal Migration.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.029
Abstract: The mammalian neocortex has undergone remarkable changes through evolution. A consequence of such rapid evolutionary events could be a trade-off that has rendered the brain susceptible to certain neurodevelopmental and neuropsychiatric conditions. We analyzed the… read more here.
Keywords: brain; plekhg6; primate specific; neuronal migration ... See more keywords
The blueprint of primate preimplantation development
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.107
Abstract: Preimplantation development in rodent and primate establishes the founding cell population of the foetus in the epiblast and segregates two extraembryonic lineages, trophoblast and hypoblast. Most of our current knowledge about these cell-fate decisions is… read more here.
Keywords: cell; development; primate specific; preimplantation development ... See more keywords
Primate-specific 82-kDa choline acetyltransferase attenuates progression of Alzheimer’s disease-like pathology in the APPNL-G-F knock-in mouse model
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-78751-2
Abstract: Alzheimer’s disease (AD) is characterized by amyloidosis, neuroinflammation, cholinergic dysfunction and cognitive impairment. In AD, the cholinergic neuronal marker choline acetyltransferase (ChAT) is reduced and the primate-specific nuclear isoform, 82-kDa ChAT, is mislocalized to cytoplasm.… read more here.
Keywords: alzheimer disease; pathology; kda chat; primate specific ... See more keywords
TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adl2036
Abstract: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by preferential neuronal loss in the striatum. The mechanism underlying striatal selective neurodegeneration remains unclear, making it difficult to develop effective treatments for HD. In… read more here.
Keywords: disease; trim37; huntington disease; primate specific ... See more keywords
Dysregulation of an X-linked primate-specific epididymal microRNA cluster in unexplained asthenozoospermia
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18076
Abstract: Asthenoszoopermia, characterized by reduced sperm motility, is one of the primary forms of male infertility. Whereas most cases were diagnosed into unexplained asthenozoospermia (UA) because the etiology cannot be identified. In animal models, epigenetic dysregulation… read more here.
Keywords: unexplained asthenozoospermia; primate specific; mir; dysregulation ... See more keywords
Transcriptional Regulators and Human-Specific/Primate-Specific Genes in Neocortical Neurogenesis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21134614
Abstract: During development, starting from a pool of pluripotent stem cells, tissue-specific genetic programs help to shape and develop functional organs. To understand the development of an organ and its disorders, it is important to understand… read more here.
Keywords: primate specific; transcriptional regulators; neurogenesis; regulators human ... See more keywords