PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors
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DOI: 10.1016/j.stemcr.2016.12.010
Abstract: Summary In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneously, fluctuating between a PDGFRα+… read more here.
Keywords: cell; pre implantation; primitive endoderm; pre ... See more keywords
Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm
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DOI: 10.1093/nar/gkac054
Abstract: Abstract The second cell fate decision in the early stage of mammalian embryonic development is pivotal; however, the underlying molecular mechanism is largely unexplored. Here, we report that Prmt1 acts as an important regulator in… read more here.
Keywords: primitive endoderm; pre; cell; klf4 methylated ... See more keywords
Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling
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DOI: 10.1111/cpr.70088
Abstract: Lactate has been widely recognised as an energy source and metabolic by‐product, but increasing evidence supports its critical role as a signalling molecule or epigenetic substrate. During early embryogenesis, lactate production increases during the transition… read more here.
Keywords: pre; second cell; cell; cell fate ... See more keywords