PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors
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DOI: 10.1016/j.stemcr.2016.12.010
Abstract: Summary In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneously, fluctuating between a PDGFRα+… read more here.
Keywords: cell; pre implantation; primitive endoderm; pre ... See more keywords
Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac054
Abstract: Abstract The second cell fate decision in the early stage of mammalian embryonic development is pivotal; however, the underlying molecular mechanism is largely unexplored. Here, we report that Prmt1 acts as an important regulator in… read more here.
Keywords: primitive endoderm; pre; cell; klf4 methylated ... See more keywords