Effect of estrogen on chick primordial follicle development and activation
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10766
Abstract: Steroid hormones and their receptors play pivotal roles in avian reproduction and development. 17β‐estradiol (E2) is an essential mediator in ovarian development. In this study, Day 3 (D3) chicks were injected with E2 (0.025, 0.25… read more here.
Keywords: follicle development; development activation; effect; primordial follicle ... See more keywords
The impact of oocyte death on mouse primordial follicle formation and ovarian reserve
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12489
Abstract: Ovaries, the source of oocytes, maintain the numbers of primordial follicles, develop oocytes for fertilization and embryonic development. Although it is well known that about two‐thirds of oocytes are lost during the formation of primordial… read more here.
Keywords: impact oocyte; mouse primordial; oocyte death; formation ... See more keywords
Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.02.020
Abstract: Background Global consumption of protein per capita is rising, while rates of infertility are increasing. However, a clear relationship between protein intake and reproductive health has not been demonstrated. The activation of the quiescent primordial… read more here.
Keywords: follicle; primordial follicle; activation; follicle reserve ... See more keywords
Di (2-ethylhexyl) phthalate impairs primordial follicle assembly by increasing PDE3A expression in oocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.116088
Abstract: It is known that Di (2-ethylhexyl) phthalate (DEHP) may impact mammalian reproduction and that in females one target of the drug's action is follicle assembly. Here we revisited the phthalate's action on the ovary and… read more here.
Keywords: follicle assembly; follicle; primordial follicle; expression ... See more keywords
Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114714
Abstract: Ovarian toxicity and infertility are major side effects of cancer therapy in young female cancer patients. We and others have previously demonstrated that doxorubicin (DOX), one of the most widely used chemotherapeutic chemicals, has a… read more here.
Keywords: dox induced; overactivation; obliterates mouse; follicle ... See more keywords
Bone morphogenetic protein 2- and estradiol-17β-induced changes in ovarian transcriptome during primordial follicle formation
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac111
Abstract: Abstract Estradiol-17β has been shown to promote primordial follicle formation and to involve bone morphogenetic protein 2 (BMP2) as a downstream effector to promote primordial follicle in hamsters. However, the molecular mechanism whereby these factors… read more here.
Keywords: estradiol; follicle formation; primordial follicle; bmp2 ... See more keywords
P-444 Presence of pharmacological inhibitors of the PI3K/PTEN/Akt and mTOR signalling pathways during cryopreservation and organotypic cultures of murine ovaries limits early primordial follicle depletion
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction"
DOI: 10.1093/humrep/deab127.006
Abstract: Which signalling pathways are implicated in primordial follicle activation induced by cryopreservation and/or organotypic culture? Is it possible to limit this activation through pharmacological inhibitors? Our findings provide support for the hypothesis that mTOR and… read more here.
Keywords: signalling pathways; follicle; primordial follicle; cryopreservation ... See more keywords
The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing
Sign Up to like & getrecommendations! Published in 2018 at "Human Reproduction Update"
DOI: 10.1093/humupd/dmy002
Abstract: BACKGROUND Within the ovary, oocytes are stored in long-lived structures called primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic granulosa cells. It is essential that their genetic integrity is maintained throughout life… read more here.
Keywords: follicle oocytes; dna repair; dna; primordial follicle ... See more keywords
Comparison of methods for quantifying primordial follicles in the mouse ovary
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-020-00724-6
Abstract: Background Accurate evaluation of primordial follicle numbers in mouse ovaries is an essential endpoint for studies investigating how endogenous and exogenous insults, such as maternal aging and chemotherapy, impact the ovarian reserve. In this study,… read more here.
Keywords: primordial follicles; direct count; follicle; method ... See more keywords
Identification of Biomarkers for Predicting Ovarian Reserve of Primordial Follicle via Transcriptomic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.879974
Abstract: Ovarian reserve (OR) is mainly determined by the number of primordial follicles in the ovary and continuously depleted until ovarian senescence. With the development of assisted reproductive technology such as ovarian tissue cryopreservation and autotransplantation,… read more here.
Keywords: ovarian reserve; identification biomarkers; biomarkers predicting; follicle ... See more keywords
Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1113684
Abstract: Primordial follicles are the starting point of follicular development and the basic functional unit of female reproduction. Primordial follicles are formed around birth, and most of the primordial follicles then enter a dormant state. Since… read more here.
Keywords: primordial follicles; mechanisms primordial; follicle activation; activation ... See more keywords