P0045GENETIC ABLATION OF NFAT5 IN THE PRINCIPAL CELLS OF THE COLLECTING DUCT LEADS TO A WATER HANDLING DEFECT
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DOI: 10.1093/ndt/gfaa144.p0045
Abstract: Nuclear Factor of Activated T-Cells 5 (NFAT5), also called TonEBP/OREBP, helps protecting kidney cells from the stress of extracellular hypertonic challenge. In response to hypertonicity, NFAT5 rapidly translocates into the nucleus and enhances the transcription… read more here.
Keywords: duct leads; water; nfat5f aqp2cre; mice ... See more keywords
Stimulation of the Epithelial Na+ Channel in Renal Principal Cells by Gs-Coupled Designer Receptors Exclusively Activated by Designer Drugs
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DOI: 10.3389/fphys.2021.725782
Abstract: The activity of the Epithelial Na+ Channel (ENaC) in renal principal cells (PC) fine-tunes sodium excretion and consequently, affects blood pressure. The Gs-adenylyl cyclase-cAMP signal transduction pathway is believed to play a central role in… read more here.
Keywords: designer; specific gsd; mice; activity ... See more keywords
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells
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DOI: 10.3390/ijms23020763
Abstract: The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms controlling the localization of AQP2 are… read more here.
Keywords: controlling localization; localization; principal cells; inhibitor ... See more keywords
Reorganization of Parvalbumin Immunopositive Perisomatic Innervation of Principal Cells in Focal Cortical Dysplasia Type IIB in Human Epileptic Patients
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DOI: 10.3390/ijms23094746
Abstract: Focal cortical dysplasia (FCD) is one of the most common causes of drug-resistant epilepsy. As several studies have revealed, the abnormal functioning of the perisomatic inhibitory system may play a role in the onset of… read more here.
Keywords: principal cells; cortical dysplasia; type iib; perisomatic inhibitory ... See more keywords