Changepoint inference in the presence of missing covariates for principal surrogate evaluation in vaccine trials
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DOI: 10.1093/biomet/asaa100
Abstract: We consider the use of threshold-based regression models to evaluate immune response biomarkers as principal surrogate markers of a vaccine’s protective effect. Threshold-based regression models, which allow the relationship between a clinical outcome and a… read more here.
Keywords: vaccine efficacy; missing covariates; principal surrogate; vaccine ... See more keywords