Abstract 3105: Design principle of heparanase inhibitors: A combined in vitro and in silico study
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DOI: 10.1158/1538-7445.am2023-3105
Abstract: Heparanase (HPSE) is an endo-β-D-glucuronidase and the only known enzyme responsible for the cleavage of heparan sulfate (HS) side chains from heparan sulfate proteoglycans (HSPGs). The enzymatic activity of HPSE mediates ECM remodeling, regulates growth… read more here.
Keywords: small molecule; principle heparanase; hpse; heparanase ... See more keywords