Phase separation of a yeast prion protein promotes cellular fitness
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aao5654
Abstract: Biophysical responses of proteins to stress Much recent work has focused on liquid-liquid phase separation as a cellular response to changing physicochemical conditions. Because phase separation responds critically to small changes in conditions such as… read more here.
Keywords: prion domain; phase separation; prion; domain ... See more keywords
Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00044-21
Abstract: Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions, providing a powerful system to study prionization. Previously, we demonstrated that Swi1, a component of… read more here.
Keywords: residues swi1; prion; prion domain; prion formation ... See more keywords