Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance
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DOI: 10.1128/mcb.00044-21
Abstract: Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions, providing a powerful system to study prionization. Previously, we demonstrated that Swi1, a component of… read more here.
Keywords: residues swi1; prion; prion domain; prion formation ... See more keywords
Implications of the Actin Cytoskeleton on the Multi-Step Process of [PSI+] Prion Formation
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DOI: 10.3390/v14071581
Abstract: Yeast prions are self-perpetuating misfolded proteins that are infectious. In yeast, [PSI+] is the prion form of the Sup35 protein. While the study of [PSI+] has revealed important cellular mechanisms that contribute to prion propagation,… read more here.
Keywords: prion; multi step; prion formation; step process ... See more keywords