PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02729-2
Abstract: Prion diseases are kinds of fatal neurodegenerative diseases without effective therapeutic and prophylactic tools currently. In this study, the inhibition of PrPSc propagation and cellular protectivity of 3,4-dihydroxybenzalacetone (DBL), a small catechol-containing compound isolated and… read more here.
Keywords: prion infected; inhibition; cell; dbl prion ... See more keywords
RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
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DOI: 10.1186/s13041-020-00610-8
Abstract: Background Prion diseases and prion-like disorders, including Alzheimer’s disease and Parkinson’s disease, are characterized by gliosis and accumulation of misfolded aggregated host proteins. Ablating microglia in prion-infected brain by treatment with the colony-stimulating factor-1 receptor… read more here.
Keywords: analysis; prion; prion infection; expression ... See more keywords
Lack of the immune adaptor molecule SARM1 accelerates disease in prion infected mice and is associated with increased mitochondrial respiration and decreased expression of NRF2
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DOI: 10.1371/journal.pone.0267720
Abstract: Prion diseases are a group of fatal, transmissible neurodegenerative diseases of mammals. In the brain, axonal loss and neuronal death are prominent in prion infection, but the mechanisms remain poorly understood. Sterile alpha and heat/Armadillo… read more here.
Keywords: prion; molecule; sarm1; mitochondrial respiration ... See more keywords
Characterization of physiochemical properties of caveolin-1 from normal and prion-infected human brains.
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DOI: 10.18632/oncotarget.19431
Abstract: Caveolin-1 is a major component protein of the caveolae-a type of flask shaped, 50-100 nm, nonclathrin-coated, microdomain present in the plasma membrane of most mammalian cells. Caveolin-1 functions as a scaffolding protein to organize and… read more here.
Keywords: properties caveolin; caveolin; characterization physiochemical; physiochemical properties ... See more keywords