RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
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DOI: 10.1186/s13041-020-00610-8
Abstract: Background Prion diseases and prion-like disorders, including Alzheimer’s disease and Parkinson’s disease, are characterized by gliosis and accumulation of misfolded aggregated host proteins. Ablating microglia in prion-infected brain by treatment with the colony-stimulating factor-1 receptor… read more here.
Keywords: analysis; prion; prion infection; expression ... See more keywords
Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0742-2
Abstract: For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human cerebral organoids are self-organizing, three-dimensional brain tissues that can be grown from induced pluripotent… read more here.
Keywords: sporadic creutzfeldt; prion; prion infection; disease ... See more keywords