A Small‐Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity
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DOI: 10.1002/cmdc.201700302
Abstract: Into the fold: Prion diseases are neurodegenerative disorders characterized by the accumulation in the brain of a self-replicating, misfolded isoform (PrPSc ) of the cellular prion protein (PrPC ). No therapies are available for these… read more here.
Keywords: prion protein; prion; prion replication; toxicity ... See more keywords
Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?
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DOI: 10.3390/v11050429
Abstract: Prions are proteinaceous infectious agents responsible for a range of neurodegenerative diseases in animals and humans. Prion particles are assemblies formed from a misfolded, β-sheet rich, aggregation-prone isoform (PrPSc) of the host-encoded cellular prion protein… read more here.
Keywords: protein; replication process; heterogeneity; prion ... See more keywords