Decrease in Skin Prion-Seeding Activity of Prion-Infected Mice Treated with a Compound Against Human and Animal Prions: a First Possible Biomarker for Prion Therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02418-6
Abstract: Previous studies have revealed that the infectious scrapie isoform of prion protein (PrPSc) harbored in the skin tissue of patients or animals with prion diseases can be amplified and detected through the serial protein misfolding… read more here.
Keywords: prion; seeding activity; prion diseases; prion seeding ... See more keywords
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam7785
Abstract: Infectious prions can be detected in the skin of patients with sporadic Creutzfeldt-Jakob disease. Prions in unexpected places Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, can be transmitted via neurosurgical instruments or… read more here.
Keywords: prion; skin; disease; seeding activity ... See more keywords