Multisite Skin Biopsies vs Cerebrospinal Fluid for Prion Seeding Activity in the Diagnosis of Prion Diseases.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2024.3458
Abstract: Importance Recent studies have revealed that autopsy skin samples from cadavers with prion diseases (PRDs) exhibited a positive prion seeding activity similar to cerebrospinal fluid (CSF). It is worthwhile to validate the findings with a… read more here.
Keywords: cohort; csf; skin; prion ... See more keywords
Decrease in Skin Prion-Seeding Activity of Prion-Infected Mice Treated with a Compound Against Human and Animal Prions: a First Possible Biomarker for Prion Therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02418-6
Abstract: Previous studies have revealed that the infectious scrapie isoform of prion protein (PrPSc) harbored in the skin tissue of patients or animals with prion diseases can be amplified and detected through the serial protein misfolding… read more here.
Keywords: prion; seeding activity; prion diseases; prion seeding ... See more keywords
Detection of Human Prion Seeding Activity in Formalin‐Fixed Paraffin‐Embedded Archival Tissues
Sign Up to like & getrecommendations! Published in 2025 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.70028
Abstract: Formalin‐fixed paraffin‐embedded (FFPE) samples, routinely used in neuropathology, represent an invaluable resource for studying rare diseases like transmissible spongiform encephalopathies (TSE). Despite fixation‐induced protein cross‐linking, prion seeding activity can be effectively detected using the seeding… read more here.
Keywords: formalin fixed; prion seeding; seeding activity; fixed paraffin ... See more keywords
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam7785
Abstract: Infectious prions can be detected in the skin of patients with sporadic Creutzfeldt-Jakob disease. Prions in unexpected places Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, can be transmitted via neurosurgical instruments or… read more here.
Keywords: prion; skin; disease; seeding activity ... See more keywords
Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease
Sign Up to like & getrecommendations! Published in 2024 at "BMC Neurology"
DOI: 10.1186/s12883-024-03590-7
Abstract: Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging. Even though real-time quaking-induced conversion (RT-QuIC) assay… read more here.
Keywords: blood samples; prion disease; blood; prion ... See more keywords
Prion Seeding Activity in Plant Tissues Detected by RT-QuIC
Sign Up to like & getrecommendations! Published in 2024 at "Pathogens"
DOI: 10.3390/pathogens13060452
Abstract: Prion diseases such as scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) affect domesticated and wild herbivorous mammals. Animals afflicted with CWD, the transmissible spongiform encephalopathy of cervids (deer, elk, and moose), shed… read more here.
Keywords: plant; plant tissues; prion; prion seeding ... See more keywords