Cell biology of prion strains in vivo and in vitro.
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DOI: 10.1007/s00441-021-03572-y
Abstract: The properties of infectious prions and the pathology of the diseases they cause are dependent upon the unique conformation of each prion strain. How the pathology of prion disease correlates with different strains and genetic… read more here.
Keywords: pathology; cell; prion; biology ... See more keywords
Independent amplification of co-infected long incubation period low conversion efficiency prion strains
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DOI: 10.1371/journal.ppat.1007323
Abstract: Prion diseases are caused by a misfolded isoform of the prion protein, PrPSc. Prion strains are hypothesized to be encoded by strain-specific conformations of PrPSc and prions can interfere with each other when a long-incubation… read more here.
Keywords: strain; prion; incubation period; prion strains ... See more keywords
Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
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DOI: 10.1371/journal.ppat.1010947
Abstract: Prion strains in a given type of mammalian host are distinguished by differences in clinical presentation, neuropathological lesions, survival time, and characteristics of the infecting prion protein (PrP) assemblies. Near-atomic structures of prions from two… read more here.
Keywords: prion; prp; prion strains; conformational determinants ... See more keywords
Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases
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DOI: 10.3390/v13122453
Abstract: Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a group of neurodegenerative protein misfolding diseases that invariably cause death. TSEs occur when the endogenous cellular prion protein (PrPC) misfolds to form the pathological… read more here.
Keywords: natural hosts; differential accumulation; prion; prion diseases ... See more keywords