Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses
Sign Up to like & getrecommendations! Published in 2021 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2021.105075
Abstract: T-cell-mediated immunity to SARS-CoV-2-derived peptides in individuals unexposed to SARS-CoV-2 has been previously reported. This pre-existing immunity was suggested to largely derive from prior exposure to ‘common cold’ endemic human coronaviruses (HCoVs). To test this,… read more here.
Keywords: pre existing; cell mediated; prior exposure; sars cov ... See more keywords
Risk of severe COVID-19 infection among adults with prior exposure to children
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204141119
Abstract: Significance Epidemiologic data consistently show strong protection for young children against severe COVID-19 illness. Several mechanisms have been proposed to explain this phenomenon, including cross-reactive immunity—in which prior exposure to non-SARS-CoV-2 coronaviruses that commonly infect… read more here.
Keywords: young children; prior exposure; severe covid; risk ... See more keywords
Is the lack of prior exposure to sperm antigens associated with worse neonatal and maternal outcomes? A 10‐year single‐center experience comparing ICSI–TESE pregnancies to ICSI pregnancies
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13194
Abstract: Nowadays, pathogenesis of preeclampsia (PE) is still unknown. Among the different etiological hypotheses, some authors proposed that it might be because of an abnormal immunologic response to a foreign fetal antigen derived from the father's… read more here.
Keywords: exposure sperm; prior exposure; lack prior; sperm antigens ... See more keywords
Prior Exposure to Coxsackievirus A21 Does Not Mitigate Oncolytic Therapeutic Efficacy
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DOI: 10.3390/cancers13174462
Abstract: Simple Summary Viruses are being explored as a treatment strategy for cancer by exploiting their ability to infect and kill malignant cells. Viruses also engage the immune system to promote the recognition and clearance of… read more here.
Keywords: tumor; immunity; efficacy; prior exposure ... See more keywords
Dolutegravir-Based Regimen Ensures High Virological Success despite Prior Exposure to Efavirenz-Based First-LINE ART in Cameroon: An Evidence of a Successful Transition Model
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DOI: 10.3390/v15010018
Abstract: To ensure optimal prescribing practices in the dolutegravir-era in Cameroon, we compared first-line virological response (VR) under tenofovir + lamivudine + dolutegravir (TLD) according to prior exposure to tenofovir + lamivudine + efavirenz (TLE). A… read more here.
Keywords: prior exposure; first line; tld; among tlds ... See more keywords
Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine
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DOI: 10.7554/elife.80652
Abstract: Background: Both sex and prior exposure to pathogens are known to influence responses to immune challenges, but their combined effects are not well established in humans, particularly in early innate responses critical for shaping subsequent… read more here.
Keywords: prior exposure; hsv; sex; vaccine ... See more keywords