Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2016.11.017
Abstract: Autophagy is involved in both innate and adaptive immune regulation. We propose that autophagy regulates activation of TLR3 in macrophages and is thereby essential for development of pristane-induced arthritis. We found that pristane treatment induced… read more here.
Keywords: stat1 irf1; pristane; irf1 tlr3; tlr3 ... See more keywords
Pristane promotes anaerobic glycolysis to facilitate proinflammatory activation of macrophages and development of arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112404
Abstract: Pristane-induced arthritis (PIA) could be adoptively transferred by splenic T cells in rats, and innate immunity should play critical roles in T cell activation. However, in pre-clinical stage, the activation mechanism of innate cells like… read more here.
Keywords: glycolysis; pristane; activation; arthritis ... See more keywords
Type 1 Interferon Promotes RBC Alloimmunization in a Lupus Mouse Model
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DOI: 10.1182/blood-2019-130903
Abstract: Background: Red blood cell (RBC) alloimmunization can follow exposure to foreign RBC antigens during transfusion therapy and during pregnancy/delivery. Alloantibodies against RBC antigens can cause potentially fatal hemolytic transfusion reactions and hemolytic disease of the… read more here.
Keywords: alloimmunization; pristane; transfusion; rbc alloimmunization ... See more keywords
MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristane-induced lupus
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DOI: 10.1371/journal.pone.0181015
Abstract: Objective We herein examine the role of endogenous miR155 in the development of systemic manifestations in pristane induced lupus. Materials and methods Systemic lupus in miR155-deficient and wild type mice was induced upon injection of… read more here.
Keywords: pristane induced; pristane; induced lupus; mice ... See more keywords
Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00408
Abstract: We previously showed that all-trans-retinoic acid (tRA), an active metabolite of vitamin A, exacerbated pre-existing autoimmunity in lupus; however, its effects before the development of autoimmunity are unknown. Here, using a pristane-induced model, we show… read more here.
Keywords: pristane induced; pristane; acid exerts; disease ... See more keywords
cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1010764
Abstract: Introduction Type I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated… read more here.
Keywords: cgas mice; pristane; pathology; activation ... See more keywords