Iguratimod ameliorates nephritis by modulating the Th17/Treg paradigm in pristane-induced lupus.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107563
Abstract: OBJECTIVE Iguratimod, an anti-rheumatic drug, has been widely used in the treatment of rheumatoid arthritis, but is still at an investigative stage for treatment of systemic lupus erythematosus (SLE). We examined the therapeutic effects of… read more here.
Keywords: th17 treg; pristane induced; induced lupus; iguratimod ... See more keywords
AB0155 1,25 dihydroxyvitamin d supplementation reduces hind paw edema in pristane-induced lupus model
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6619
Abstract: Background Systemic lupus erythematosus (SLE) is a multifactorial, autoimmune inflammatory disease with pleomorphic clinical manifestations involving different organs and tissues. Vitamin D (VITD) deficiency is highly prevalent and evidence is mounting that it contributes to… read more here.
Keywords: supplementation; pristane induced; vitd; induced lupus ... See more keywords
Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/1267038
Abstract: Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular… read more here.
Keywords: induced arthritis; pristane induced; immune response; mice ... See more keywords
miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/1928405
Abstract: Pristane-induced arthritis (PIA) in mice is an experimental model that resembles human rheumatoid arthritis, a chronic autoimmune disease that affects joints and is characterized by synovial inflammation and articular cartilage and bone destruction. AIRmax and… read more here.
Keywords: induced arthritis; pristane induced; expression; arthritis ... See more keywords
Metformin improves FOXP3 mRNA expression through suppression of interferon gamma levels in pristane-induced murine models of lupus.
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.23471.1
Abstract: Background: A recent study has indicated the potential of metformin therapy for lupus in animal models, but there has been no study evaluating the effect on pristane-induced lupus. This study aims to evaluate the effect… read more here.
Keywords: oral metformin; foxp3 mrna; mrna expression; pristane induced ... See more keywords
MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristane-induced lupus
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DOI: 10.1371/journal.pone.0181015
Abstract: Objective We herein examine the role of endogenous miR155 in the development of systemic manifestations in pristane induced lupus. Materials and methods Systemic lupus in miR155-deficient and wild type mice was induced upon injection of… read more here.
Keywords: pristane induced; pristane; induced lupus; mice ... See more keywords
Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00408
Abstract: We previously showed that all-trans-retinoic acid (tRA), an active metabolite of vitamin A, exacerbated pre-existing autoimmunity in lupus; however, its effects before the development of autoimmunity are unknown. Here, using a pristane-induced model, we show… read more here.
Keywords: pristane induced; pristane; acid exerts; disease ... See more keywords