Natural product derived privileged scaffolds in drug discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2018.12.007
Abstract: The biological activity and structural diversity of natural products are unsurpassed by any available synthetic screening libraries. As such, these privileged scaffolds serve as important, biologically prevalidated platforms for the design of compound libraries in… read more here.
Keywords: derived privileged; drug; privileged scaffolds; natural product ... See more keywords
Privileged Scaffolds Targeting Bromodomain-containing Protein 4.
Sign Up to like & getrecommendations! Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026622666220209143949
Abstract: In recent years, bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra terminal domain (BET) family, has been one of the most widely studied targets. BRD4 is a transcriptional regulation factor, which regulates… read more here.
Keywords: bromodomain containing; scaffolds targeting; privileged scaffolds; cancer ... See more keywords