Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes.
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DOI: 10.1101/gr.212803.116
Abstract: Understanding how regulatory sequences interact in the context of chromosomal architecture is a central challenge in biology. Chromosome conformation capture revealed that mammalian chromosomes possess a rich hierarchy of structural layers, from multi-megabase compartments to… read more here.
Keywords: analysis; privileged scale; reciprocal insulation; insulation ... See more keywords